|
| 粪菌移植治疗非酒精性脂肪性肝病研究进展 |
| Advances in fecal microbiota transplantation |
| |
| DOI：10.3969/j.issn.1007-8134.2019.04.003 |
| 中文关键词: 非酒精性脂肪性肝病 肠道菌群 粪菌移植 肝-肠轴 分子机制 |
| 英文关键词: non-alcoholic fatty liver disease intestinal bacteria fecal microbiota transplantation gut-liver axis molecular mechanism |
| 基金项目:广东省科技计划项目（2015A030302085，2016A020212022） |
|
| 摘要点击次数: 413 |
| 全文下载次数: 376 |
| 中文摘要: |
| 非酒精性脂肪肝病（non-alcoholic fatty liver disease, NAFLD）的发病率在世界范围内呈明显上升趋势，由于目前尚无确切的特效治疗方式，严重影响人类健康。近年来，越来越多的研究表明肠道菌群通过肝-肠轴影响肝功能，肠道菌群失调是NAFLD发病的重要原因。因此，纠正肠道菌群失调，可以预防和减轻NAFLD的发生、发展。粪菌移植（fecal microbiota transplantation, FMT）被认为是纠正肠道菌群失调最有效的方法，但其在NAFLD中的治疗作用还未明确。此外，FMT治疗NAFLD的潜在分子机制也尚未阐明。本文就FMT治疗NAFLD的研究现状进行总结，并发掘其潜在的分子机制，为FMT作为治疗NAFLD的有效手段提供理论支持。 |
| 英文摘要: |
| The incidence of non-alcoholic fatty liver disease (NAFLD) is significantly rising worldwide, and seriously affects human health because there is no approved drug for the treatment of NAFLD currently. Recently, increasing studies have demonstrated that intestinal bacteria affect liver function through the gut-liver axis, and the imbalance of intestinal bacterial composition is the key cause in the pathogenesis of NAFLD. Correcting intestinal bacterial imbalance, therefore, may prevent the development and attenuate the progression of NAFLD. Fecal microbiota transplantation (FMT) is considered the most effective method to correct intestinal bacteria imbalance, but its therapeutic role in NAFLD has not been established. Moreover, the potential molecular mechanisms of FMT for NAFLD have not been elucidated. This paper summarizes the currently available research results on the therapeutic effects of FMT for NAFLD, and proposes the underlying molecular mechanisms, which provide theoretical support for FMT as a useful modality for the treatment of NAFLD. |
|
HTML
查看全文
下载PDF阅读器 |
| 关闭 |