| Objective To explore the current situation and influencing factors of neonatal nosocomial infection in a hospital of Guanghan City. Methods Nine hundred and sixty-four neonates born in Guanghan People’s Hospital from September 2016 to November 2017 were selected. The clinical data of neonates were collected and analyzed retrospectively. The incidence of nosocomial infection in neonates was calculated. The independent risk factors affecting neonatal nosocomial infection were analyzed by multivariate Logistic regression. Results In 964 neonates, 41 had nosocomial infection, the incidence of infection was 4.25%. Respiratory infection was the most common type of infection, accounting for 25 cases (60.97%), followed by blood infection in 9 cases (21.95%) and skin infection in 7 cases (17.07%). The results of bacterial culture showed that there were 25 Gram-negative bacilli (60.97%), including 14 strains of Escherichia coli (34.14%) and 11 strains of Klebsiella pneumoniae (26.82%), 14 strains of Gram-positive cocci (34.14%), including 4 strains of Staphylococcus aureus (9.75%) and 8 strains of Enterococcus (19.51%); and 2 strains of fungi (4.87%). Gestational age, body mass, Apgar score, use of ventilator, invasive operation, hospitalization stay ＞ 1 week were single factors affecting neonatal nosocomial infection, the difference was statistically significant (P＜0.05). Multivariate Logistic analysis showed that body mass (＜ 2.5 kg), Apgar score (＜ 5 points), use of ventilator, invasive operation and hospitalization stay ＞ 1 week were independent risk factors affecting neonatal nosocomial infection and the difference was statistically significant (P＜0.05). Gestational age was not an independent risk factor affecting neonatal nosocomial infection (P＞0.05). Conclusions Newborns still have a chance to develop nosocomial infections. Body mass, Apgar score, use of ventilator, invasive operation and hospitalization stay are the risk factors of nosocomial infection. |