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| 血液相关标志物在社区获得性肺炎病程中的表达及意义 |
| Expression and significance of blood-related markers in the course of community-acquired pneumonia |
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| DOI：10.3969/j.issn.1007-8134.2019.04.018 |
| 中文关键词: 社区获得性肺炎 CURB-65评分 超敏C反应蛋白 降钙素原 红细胞体积分布宽度 中性粒细胞淋巴细胞比值 |
| 英文关键词: community-acquired pneumonia CURB-65 score hyper-sensitive C-reactive protein procalcitonin red blood cell distribution width neutrophil to lymphocyte ratio |
| 基金项目:安徽省自然科学基金面上项目（1508085MH192） |
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| 中文摘要: |
| 目的 研究社区获得性肺炎（community-acquired pneumonia, CAP）患者治疗过程中血液相关标志物水平，探讨其在疾病转归中的意义。方法 选取2017年2月—2018年1月我院收治的76例CAP患者作为研究对象，根据CURB-65评分，将其分为高危组、中危组和低危组，检测患者入院时（24 h内）及抗感染治疗后5 d血液中超敏C反应蛋白（hyper-sensitive C-reactive protein, hs-CRP）、降钙素原（procalcitonin, PCT）、红细胞体积分布宽度（red blood cell distribution width, RDW）以及中性粒细胞淋巴细胞比值（neutrophil to lymphocyte ratio, NLR），比较分析上述指标与CAP严重程度及疗效的相关性。结果 入院时，高危组hs-CRP、PCT、RDW和NLR的表达水平分别为（8.82±2.10） mg/L、（14.16±3.46） ng/ml、（16.28±3.46） %、7.38±1.84，明显高于中危组和低危组（P均＜0.05）；治疗5 d后，中危组和低危组血液hs-CRP、PCT、RDW和NLR水平逐渐下降，高危组则呈上升趋势（P均＜0.05）；hs-CRP、PCT、RDW和NLR与CURB-65评分均呈正相关（P均＜0.05）。结论 血液相关标志物hs-CRP、PCT、RDW和NLR均与CAP严重程度呈正相关，有助于提高临床医生对CAP患者病情严重程度判断的准确性。 |
| 英文摘要: |
| Objective To investigate the levels of blood-related markers in patients with community-acquired pneumonia (CAP) during the course of treatment, and to explore its significance in the disease outcome. Methods Seventy-six CAP patients who were admitted in our hospital from February 2017 to January 2018 were included. According to the CURB-65 score, they were divided into high-risk group, middle-risk group and low-risk group. The levels of hyper-sensitive C-reactive protein (hs-CRP), procalcitonin (PCT), red blood cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) were measured at admission (within 24 hours) and after 5-day anti-infection treatment. The correlation of these markers with CAP severity and treatment efficacy was analyzed and compared. Results At admission, the expression levels of hs-CRP, PCT, RDW and NLR in high-risk group were (8.82±2.10) mg/L, (14.16±3.46) ng/ml, (16.28±3.46)%, 7.38±1.84, which were significantly higher than those in middle-risk group and low-risk group (P＜0.05); at 5 days after treatment. The blood levels of hs-CRP, PCT, RDW and NLR in middle-risk group and low-risk group decreased gradually, while those in high-risk group showed an upward trend (P＜0.05). The hs-CRP, PCT, RDW and NLR were positively correlated with the CURE-65 scores. Conclusions The blood-related markers including hs-CRP, PCT, RDW and NLR are positively correlated with the severity of CAP. This finding will help to improve the accuracy of clinical physician on judging the severity of CAP. |
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