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| MicroRNA在非酒精性脂肪性肝病发病过程中作用的研究进展 |
| Progress of microRNA in the development of non-alcoholic fatty liver disease |
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| DOI：10.3969/j.issn.1007-8134.2019.04.024 |
| 中文关键词: 非编码RNA 非酒精性脂肪性肝病 致病机制 纤维化 |
| 英文关键词: non-coding RNA non-alcoholic fatty liver disease pathogenesis fibrosis |
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| 中文摘要: |
| 微小RNA（microRNA, miRNA）是一种小的非编码RNA，参与机体的生理和病理反应。非酒精性脂肪性肝病（non-alcoholic fatty liver disease, NAFLD）是以弥漫性肝细胞大泡性脂肪变性为主要特征的临床病理综合征。近年来，有报道称miRNA在肝脏炎症、纤维化和硬化中发挥了一定的作用，尤其是在NAFLD发生发展过程中，miRNA表达特点、致病机制、临床诊治中的意义等方面引起了较大关注，故本文对此进行综述。 |
| 英文摘要: |
| MicroRNA is small non-coding RNA that participates in physiological and pathological reactions in human body. Non-alcoholic fatty liver disease (NAFLD) refers to the clinical pathological syndrome mainly characterized by diffuse bulbous steatosis of hepatocytes. Recently, it has been reported that microRNA plays a certain role in liver inflammation, fibrosis and sclerosis, especially in the development of NAFLD. It has attracted considerable attention in the aspects of microRNA expression characteristics, pathogenesis, significance in clinical diagnosis and treatment of NAFLD. Therefore, this article reviews those recent advances. |
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