|
| 隐匿性乙型肝炎病毒感染的研究进展 |
| Research progress on occult hepatitis B virus infection |
| |
| DOI：10.3969/j.issn.1007-8134.2019.05.002 |
| 中文关键词: 隐匿性乙型肝炎病毒感染 HBV再激活 终末期肝病 |
| 英文关键词: occult hepatitis B virus infection HBV reactivation end-stage liver disease |
| 基金项目:国家自然科学基金（81572010）；首都卫生发展科研专项项目（2016-2-5032）；北京市自然科学基金（7172206） |
|
| 摘要点击次数: 412 |
| 全文下载次数: 411 |
| 中文摘要: |
| 隐匿性乙型肝炎病毒感染（occult HBV infection, OBI）是公共健康的一大难题，也是全球临床医学面临的挑战。由于目前检测方法以及临床实际问题的限制，不同研究中对于OBI的定义也不同。OBI的存在会影响临床诊断和输血安全，且OBI在临床高危人群中有再激活的风险，可能会导致肝硬化、肝癌和肝衰竭等终末期肝病。本文就近年OBI定义和不同人群流行率、OBI发生机制以及临床意义等研究进展进行综述。 |
| 英文摘要: |
| Occult hepatitis B virus infection (OBI) is a great issue for the public health and a challenge for the clinical medicine worldwide. Several definitions of OBI have been described in different researches due to present limited testing methods and clinical practice. OBI may affect the diagnosis and blood transfusion safety, and OBI reactivation is a main risk factor for clinical high-risk patients. In addition, OBI may result in end-stage liver diseases such as liver cirrhosis, hepatocellular carcinoma and liver hepatic failure. This paper reviews the definition, prevalence, mechanism and clinical implications of OBI based on recent researches. |
|
HTML
查看全文
下载PDF阅读器 |
| 关闭 |