| Objective To evaluate the risk factors of acute kidney injury (AKI) and the influencing factors for the severity of AKI in post-liver transplantation patients. Methods The patients who received a liver transplantation in our center from January 2005 to August 2015 were included in this study, while preoperative AKI patients were excluded. A total of 469 patients were enrolled. Risk factors for AKI before, during and after liver transplantation and outcomes at 4 weeks after liver transplantation were analyzed and investigated. Results Among the involved 469 patients, 274 cases appeared AKI (AKI group) and 195 cases had no AKI (non-AKI group) after liver transplantation, the AKI incidence was 58.4%. Risk factors for AKI included recipient’s body mass index (BMI), preoperative creatinine level, cold ischemia time, duration of surgery, duration of inferior vena clamping, postoperative peak lactate and postoperative peak AST. At 4 weeks after liver transplantation, 20.4% of AKI patients still had abnormal renal functions and a mortality of 3.6%, which were significantly higher than those without AKI (P=0.027). Conclusions Post-liver transplantation AKI is influenced by several factors. Recipient’s BMI, preoperative creatinine level, duration of inferior vena clamping, duration of surgery, postoperative peak lactate and postoperative peak AST are the independent risk factors for AKI. At 4 weeks post-liver transplantation, abnormal renal functions and mortality are obviously higher in patients with AKI than patients without AKI. |