| Objective To investigate the difference of estrogen level and pregnancy outcome between pregnant women with HBV and normal pregnant women, and provide evidence for clinical pregnancy of pregnant women with HBV. Methods Two hundred and twenty-six pregnant women admitted to our hospital from January 2015 to January 2018 were selected as the study objects, 116 of them were normal pregnant women as the control group, the remaining 110 of them were pregnant women with HBV as the observation group. The estrogen levels of pregnant women in 2 groups were detected, and the influence on pregnancy outcome was analyzed. Results The levels of estrone, estradiol, estriol in the observation group were significantly higher than those in the control group (P＜0.05). The incidences of pregnancy outcome such as fetal distress, neonatal asphyxia, cesarean section and premature delivery in the observation group were significantly higher than those in the control group, and the natural birth rate was significantly lower than that in the control group (P＜0.05). The incidences of complication such as proteinuria, positive urine WBC, gestational hypertension and postpartum hemorrhage in the observation group were significantly higher than those in the control group (P＜0.05). Logistic multiple regression analysis showed that high estrogen level, advanced age, long-term course of HBV, previous treatment history, high viral load and high ALT level were all risk factors for adverse pregnancy outcome (P＜0.05). Conclusions The level of estrogen secreted by pregnant women with HBV increases greatly. That further increases the load of the liver, leads to obvious abnormality of liver function, and increases incidence of adverse pregnancy outcome and pregnancy complications of pregnant women. In clinical practice, we should strengthen the detection of related indicators for pregnant women with HBV and advocate active prevention of complications. |