|
| 艾滋病功能性治愈研究新进展 |
| New advances in functional cure of acquired immunodeficiency syndrome |
| |
| DOI：10.3969/j.issn.1007-8134.2019.06.003 |
| 中文关键词: 人类免疫缺陷病毒 获得性免疫缺陷综合征 功能性治愈 基因治疗 病毒储存库 |
| 英文关键词: human immunodeficiency virus (HIV) acquired immunodeficiency syndrome (AIDS) functional cure genetic therapy viral reservoir |
| 基金项目:“十三五”国家科技重大专项课题（2018ZX10302103-002，2017ZX10202102-003-004，2017ZX10202101-003-001）；广州市科技创新委员会健康医疗协同创新重大计划课题（滚动）项目（201803040002） |
|
| 摘要点击次数: 408 |
| 全文下载次数: 424 |
| 中文摘要: |
| 抗反转录病毒治疗（antiretroviral therapy, ART）虽然能有效抑制HIV 1型（HIV-1），但不能根治AIDS。AIDS功能性治愈须为停止ART后患者体内HIV-1 RNA长期低于检测下限， CD4+ T淋巴细胞数量和机体免疫功能保持正常，这一直是全球研究热点和难点。近年来，AIDS功能性治愈研究在HIV-1储存库激活和清除、免疫治疗、干细胞移植、基因编辑等方面取得了长足进步，本文就此进行综述，为进一步研究提供理论指导。 |
| 英文摘要: |
| Although antiretroviral therapy (ART) is effective in suppressing the HIV-1, it can not cure AIDS. AIDS functional cure means the HIV-1 RNA viral load must remain undetectable for a long time after ART is terminated. The number of CD4+ T lymphocytes and immune function of patients stay normal. The functional cure for AIDS has become a global strategic priority. In recent years, researchers have made great strides towards a functional cure for HIV, especially on the HIV-1 reservoir activation and removal, immunotherapy, stem cell transplantation and gene editing. The objective of this paper is to systematically review current progress on AIDS functional cure and provides theoretical guidance for future research. |
|
HTML
查看全文
下载PDF阅读器 |
| 关闭 |