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| NK细胞过继免疫治疗HIV感染研究进展 |
| Research progress on NK cell-based adoptive immunotherapy for HIV infection |
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| DOI：10.3969/j.issn.1007-8134.2019.06.005 |
| 中文关键词: HIV感染 NK细胞 过继治疗 免疫治疗 |
| 英文关键词: HIV infection NK cells adoptive therapy immunotherapy |
| 基金项目:“十三五”国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（2017ZX10202101-004-001，2017ZX10202102-005-003）；艾滋病研究北京市重点实验室（BZ0089） |
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| 中文摘要: |
| NK细胞是天然免疫中的重要效应细胞，在机体早期抗病毒、抗肿瘤的免疫应答中起关键作用。NK细胞因其主要组织相容性复合体非限制性、泛特异性识别和杀伤靶细胞及快速应答等特点成为免疫治疗研究热点。随着对NK细胞表型、功能及作用机制研究的不断深入，NK细胞过继免疫治疗也被尝试应用于HIV感染治疗。本文从NK细胞生物学特性、NK细胞在HIV感染中的作用以及NK细胞过继免疫治疗等方面来阐述NK细胞过继治疗在HIV感染领域应用的机遇与挑战。 |
| 英文摘要: |
| NK cells are important effector cells in the innate immunity and they play a key role in the early antiviral and anti-tumor immune responses. NK cells have become the focus of immunotherapy study due to their major histocompatibility complex non-restriction, pan specific recognition, elimination of target cells and rapid immune responses. With the advanced understanding of NK cell phenotype, function and mechanism, NK cell-based adoptive immunotherapy has been applied to treat HIV infection. This review will discuss the opportunities and challenges of NK cell-based adoptive immunotherapy in the field of HIV infection through the analysis on the biological characteristics of NK cells, the role of NK cells in HIV infection and the NK cell-based adoptive immunotherapy. |
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