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| 肾综合征出血热患者血浆MCP-1水平及其临床意义 |
| Plasma levels of MCP-1 in patients with hemorrhagic fever with renal syndrome and its clinical significance |
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| DOI：10.3969/j.issn.1007-8134.2019.06.009 |
| 中文关键词: 汉坦病毒 肾综合征出血热 血浆 单核细胞趋化蛋白-1 |
| 英文关键词: hantavirus hemorrhagic fever with renal syndrome plasma monocyte chemotactic protein-1 |
| 基金项目:国家自然科学基金（81373118） |
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| 中文摘要: |
| 目的 分析肾综合征出血热（hemorrhagic fever with renal syndrome, HFRS）患者不同病期及不同临床型血浆单核细胞趋化蛋白-1（monocyte chemotactic protein-1, MCP-1）浓度变化与疾病相关性，为HFRS临床诊治提供参考依据。方法 以2012年10月—2014年1月期间在空军军医大学唐都医院住院就诊的81例HFRS患者及15例健康志愿者（正常对照组）作为研究对象，用酶联免疫吸附法分别检测其血浆中MCP-1水平，同步检测血常规、肾功能等指标，并分析MCP-1与临床常规检测指标的相关性。结果 在急性期，所有患者血浆MCP-1水平均明显升高，其中重型/危重型患者血浆MCP-1水平升高比轻型/中型更为显著；中型、重型、危重型患者血浆MCP-1水平急性期均高于恢复期及正常对照组（P均＜0.05），恢复期与正常对照组比较差异无统计学意义（P＞0.05）。Spearman相关分析显示血浆MCP-1水平与白细胞、尿素氮、肌酐水平呈正相关，与血小板水平呈负相关。结论 HFRS患者血浆MCP-1水平与疾病严重程度及疾病进程密切相关。 |
| 英文摘要: |
| Objective To analyze the correlation between plasma levels of monocyte chemotactic protein-1 (MCP-1) and the disease in patients at different phases and of different clinical types of hemorrhagic fever with renal syndrome (HFRS), and provide reference for clinical diagnosis and treatment of HFRS. Methods Eighty-one HFRS patients hospitalized in Tangdu Hospital from October 2012 to January 2014 and 15 healthy volunteers (normal control group) were enrolled as subjects. The plasma MCP-1 levels were measured using enzyme-linked immunosorbent assay. Simultaneous detection of blood routine, renal function and other indicators were performed. The correlation between MCP-1 and clinical routine detection indicators was analyzed. Results At the acute phase, plasma MCP-1 levels were significantly elevated in all patients, and the elevation in the severe/critical patients was more significant than that in the mild/moderate patients. The plasma levels of MCP-1 in the moderate, severe and critical patients at the acute stage were higher than those at the convalescent stage and in normal control group (P＜0.05). There was no significant difference in the MCP-1 levels between patients at the convalescent stage and normal controls (P＞0.05). Spearman correlation analysis indicated that plasma MCP-1 levels were positively correlated with white blood cells, blood urea nitrogen levels and serum creatinine, while they were negatively correlated with blood platelet levels. Conclusions Plasma levels of MCP-1 are closely correlated with the disease severity and the disease progression in HFRS patients. |
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