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| 与CO2冷冻治疗宫颈上皮内瘤变伴HPV感染疗效相关的影响因素分析 |
| Analysis of influencing factors related to the efficacy of CO2 cryotherapy on cervical intraepithelial neoplasia with HPV infection |
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| DOI：10.3969/j.issn.1007-8134.2019.06.016 |
| 中文关键词: CO2冷冻治疗 宫颈上皮内瘤变 HPV持续感染 危险因素 |
| 英文关键词: CO2 cryotherapy cervical intraepithelial neoplasia persistent HPV infection risk factor |
| 基金项目:首都卫生发展科研专项课题（首发2017-4-2036） |
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| 中文摘要: |
| 目的 探究CO2冷冻治疗宫颈上皮内瘤变（cervical intraepithelial neoplasia, CIN）伴人乳头瘤病毒（human papillomavirus, HPV）感染的疗效，并分析HPV持续感染的危险因素。方法 选取2018年1—11月期间在首都医科大学附属北京妇产医院治疗的CIN伴HPV感染患者560例作为研究对象，观察CIN和HPV感染的治疗效果，并采用Logistic回归分析方法探究治疗后HPV持续感染的危险因素。结果 治疗后6个月，CIN治疗的临床有效率为83.04%，HPV转阴率为73.75%；Logistic回归分析显示，年龄≥50岁、性伴侣个数≥2个、人流次数≥1次、生殖道炎症是CO2冷冻治疗后HPV持续感染的独立危险因素（P均＜0.05）。结论 CO2冷冻治疗对CIN和HPV感染清除均有一定的效果， HPV清除效果受到年龄、性伴侣个数、人流次数、生殖道炎症等因素的影响。 |
| 英文摘要: |
| Objective To explore the efficacy of CO2 cryotherapy on cervical intraepithelial neoplasia (CIN) with human papillomavirus (HPV) infection, and to analyze the risk factors of persistent HPV infection. Methods Totally 560 CIN patients with HPV infection who were treated in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 2018 to November 2018 were selected as subjects. The therapeutic effects of CIN and HPV infection were observed. Logistic regression analysis was used to explore the risk factors of persistent HPV infection after treatment. Results At 6 months after treatment, the clinical effective rate of CIN treatment was 83.04%, and the HPV negative rate was 73.75%. Logistic regression analysis showed that age ≥ 50 years, number of sexual partners ≥ 2, number of induced abortion ≥ 1, genital tract inflammation were independent risk factors of persistent HPV infection after CO2 cryotherapy (P＜0.05). Conclusions CO2 cryotherapy has a certain effect on the clearance of CIN and HPV infection. The clearance of HPV infection is affected by factors such as age, number of sexual partners, number of induced abortion and genital tract inflammation. |
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