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| 抗反转录病毒治疗时机选择对妊娠合并HIV感染者妊娠结局影响的研究 |
| Influence of the timing selection of antiretroviral therapy on pregnancy outcome of HIV-infected pregnant women |
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| DOI：10.3969/j.issn.1007-8134.2020.02.007 |
| 中文关键词: 妊娠合并HIV感染 抗反转录病毒治疗 妊娠结局 |
| 英文关键词: pregnancy with HIV infection antiretroviral therapy pregnancy outcome |
| 基金项目:四川省卫生计生委科研课题（17PJ249） |
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| 中文摘要: |
| 目的 研究抗反转录病毒治疗时机选择，明确其对妊娠合并HIV感染者妊娠结局的影响。方法 选取2015年1月—2018年1月我院收治的103例妊娠合并HIV感染者作为研究对象，根据抗反转录病毒治疗时机不同分为2组，其中在孕28周以内行抗反转录病毒治疗的患者作为研究组（n=74例）；在孕28周及以后行抗反转录病毒治疗，且至分娩间隔时间不少于1个月的患者作为对照组（n=29例）。观察2组患者抗病毒治疗效果、妊娠结局及18月龄儿HIV感染随访情况。结果 行抗反转录病毒治疗后，分娩前1 d研究组患者病毒载量下降幅度大于对照组（P＜0.05）；研究组患者早产比例为2.70%，显著低于对照组（P＜0.05）。结论 妊娠合并HIV感染者尽早实施抗反转录病毒治疗对于降低母体病毒载量和胎儿早产率具有重要意义。 |
| 英文摘要: |
| Objective To study the timing selection of antiretroviral therapy, and determine its influence on pregnancy outcome of pregnant women with HIV infection. Methods A total of 103 pregnant women with HIV infection admitted to our hospital from January 2015 to January 2018 were included in this study. They were divided into 2 groups according to the timing of receiving antiretroviral therapy. The patients who received antiretroviral therapy after the 28th week of gestation were taken as the study group (n=74); the patients who received antiretroviral therapy after the 28th week of gestation with an interval of at least one month prior to delivery were taken as the control group (n=29). Antiviral treatment effect, pregnancy outcome and follow-up results of HIV infection in 18-month-old infants in 2 groups were observed. Results After antiretroviral therapy, the decrease degree of viral load of patients in the study group was greater than that in the control group at 1 day before delivery (P＜0.05). The incidence of premature delivery in the study group was 2.70%, which was significantly lower than that in the control group (P＜0.05). Conclusions It is of great significance for HIV-infected pregnant women to carry out antiretroviral therapy as early as possible, to reduce the maternal viral load and preterm delivery rate. |
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