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| 哌拉西林/舒巴坦钠治疗 |
| Effect of piperacillin/sulbactam on serum indexes in the treatment of senile bacterial pneumonia |
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| DOI：10.3969/j.issn.1007-8134.2020.02.010 |
| 中文关键词: 老年细菌性肺炎 降钙素原 C反应蛋白 D-二聚体 |
| 英文关键词: senile bacterial pneumonia procalcitonin C-reactive protein D-dimer |
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| 中文摘要: |
| 目的 观察哌拉西林/舒巴坦钠治疗老年细菌性肺炎的临床疗效及对患者血清炎症因子等实验室指标的影响。方法 选取本院2018年1月—2019年1月间收治的106例老年细菌性肺炎患者作为研究对象，按随机数字表法分为常规组和研究组，常规组接受哌拉西林钠治疗，研究组接受哌拉西林/舒巴坦钠治疗，评估2组临床疗效；观察2组的CRP、降钙素原（procalcitonin, PCT）、D-二聚体（D-dimer, D-D）、PLT、ALB、Na+、Cl-水平的变化；比较2组的临床症状：发热、咳嗽咳痰的改善时间及住院时间，对比2组治疗期间的不良反应的发生率。结果 研究组总有效率（92.45%）明显高于常规组（69.81%）；治疗后，2组CRP、PCT、D-D的表达水平均较治疗前降低，PLT、ALB、Na+、Cl-均较治疗前回升，且研究组的血清CRP、PCT、D-D的降低幅度大于常规组， PLT、ALB、Na+、Cl-升高幅度大于常规组（P均＜0.05）；研究组的发热、咳嗽、咳痰的改善时间与住院时间均少于常规组（P均＜0.05）；研究组的不良反应发生率为22.64%，常规组为20.75%，2组差异无统计学意义（P＞0.05）。结论 哌啦西林/舒巴坦钠治疗老年细菌性肺炎的疗效理想，可通过降低血清炎症因子等机制起到控制炎症反应的作用。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of piperacillin/sulbactam sodium in the treatment of senile pneumonia and its influence on laboratory indexes such as serum inflammatory factors. Methods One hundred and six elderly patients with pneumonia treated in our hospital from January 2018 to January 2019 were included in this study. They were divided into routine group and study group according to random number table. The routine group was treated with piperacillin sodium and the study group was treated with piperacillin/sulbactam sodium. The clinical efficacy of the 2 groups was evaluated. Changes of expression levels of C-reactive protein (CRP), procalcitonin (PCT), D-dimer (D-D), PLT, ALB, sodium (Na+), chlorine (Cl-) were compared. The clinical symptoms including the improvement time of fever, cough, expectoration and length of hospital stay, and the incidence of adverse reactions during treatment between the 2 groups were compared. Results The overall effective rate in the study group (92.45%) was obviously higher than that in the routine group (69.81%). After treatment, the expression levels of CRP, PCT and D-D in serum were lower than those before treatment in the 2 groups, while PLT, ALB, serum Na+ and Cl- were higher than those before treatment. The decrease of expression levels of CRP, PCT and D-D in serum of the study group was more obvious than that in the routine group, the increase of PLT, ALB, Na+ and Cl- in the study group was also more obvious than that in the routine group (P＜0.05). The improvement time of fever, cough and expectoration, as well as the length of hospital stay in the study group were shorter than those in the routine group (P＜0.05). The incidence of adverse reactions was 22.64% in the study group and 20.75% in the routine group, with no significant difference between 2 groups. Conclusions Piperacillin/sulbactam sodium is effective in the treatment of senile pneumonia. It can control inflammatory reaction by reducing the expression of serum inflammatory factors. |
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