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| 儿童肺炎支原体肺炎治愈1年内发生反复呼吸道感染的相关因素研究 |
| Study on the related factors of recurrent respiratory tract infection within 1 year after cure of mycoplasma pneumoniae pneumonia in children |
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| DOI：10.3969/j.issn.1007-8134.2020.02.011 |
| 中文关键词: 肺炎支原体肺炎 反复呼吸道感染 儿童 相关因素 |
| 英文关键词: mycoplasma pneumoniae pneumonia recurrent respiratory tract infection children related factors |
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| 中文摘要: |
| 目的 探究儿童肺炎支原体肺炎（mycoplasma pneumoniae pneumonia, MPP）患者治愈1年内发生反复呼吸道感染（recurrent respiratory tract infections, RRTI）的相关因素。方法 对2017年3月—2018年3月间于我院治愈的78例MPP患儿定期随访1年，记录随访期间RRTI发生情况。根据是否发生RRTI，将其分为未发生组（n=47）和发生组（n=31）。统计2组患儿的一般资料并进行单因素分析，对有统计学意义的指标进行多因素Logistic回归分析。结果 78例MPP患儿随访1年期间，共有31例发生RRTI，发生率为39.74%。多因素Logistic回归分析显示：年龄3～6岁、肺炎支原体（Mycoplasma pneumoniae, MP）抗体阴转阳、MP抗体阳性、未使用免疫增强剂、CD4+/CD8+比值降低、IgA低于正常水平均为MPP患儿治愈1年内发生RRTI的独立危险因素（OR=2.551，5.709，3.017，2.325，3.024，2.486，P均＜0.05）。结论 年龄3～6岁、MP抗体阴转阳、MP抗体阳性、未使用免疫增强剂、CD4+/CD8+比值降低、IgA低于正常水平均为MP感染治愈1年内发生RRTI的独立危险因素。临床上应合理使用抗生素及糖皮质激素，积极治疗免疫功能低下患儿，加强对病情的监测及随访，改善患儿预后。 |
| 英文摘要: |
| Objective To explore the factors associated with recurrent respiratory tract infection (RRTI) within 1 year after children with mycoplasma pneumoniae pneumonia (MPP) are cured. Methods Seventy-eight children with MPP, who were cured in our hospital from March 2017 to March 2018, were regularly followed up for 1 year. The incidence of RRTI during follow-ups was recorded. The involved children were divided into non-occurrence group (n=47) and occurrence group (n=31) according to the absence or presence of RRTI. The general data of children in 2 groups were statistically analyzed and univariate analysis was carried out. The statistically significant indexes were analyzed by multivariate Logistic regression analysis. Results All 78 children with MPP were followed up for 1 year, and 31 cases had RRTI, the incidence of RRTI was 39.74%. Multivariate Logistic regression analysis showed that age of 3-6 years old, Mycoplasma pneumoniae (MP) antibody turns positive, positive by MP antibody, no application of immunopotentiator, decrease of CD4+/CD8+, and immunoglobulin A (IgA) level below normal levels were the independent risk factors of RRTI within 1 year after MPP was cured (OR=2.551, 5.709, 3.017, 2.325, 3.024, 2.486, P＜0.05). Conclusions Age of 3-6 years old, MP antibody turns positive, positive by MP antibody, no application of immunopotentiator, decrease of CD4+/CD8+, and IgA level below normal levels are independent risk factors for RRTI within 1 year after MP infection is cured. In clinical practice, reasonable application of antibiotics and glucocorticoids, active treatment of immunocompromised children, strengthening the monitoring and follow-up of the illness should be performed to improve the prognosis of children. |
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