| Objective To explore the distribution characteristics of pathogens, analyze drug resistance in children with acute bacterial dysentery and provide evidence for the treatment of acute bacterial dysentery in children. Methods Eighty children diagnosed with acute bacterial dysentery in Bozhou People’s Hospital were included in this study. The clinical data including body temperature, diarrhea frequency, fecal state and the experimental examination such as fecal pathogen culture and drug sensitivity assay were analyzed statistically. Results Among the pathogens in children with acute bacterial dysentery, S. flexneri had the highest detection rate, followed by S. sonnei, and S. boydii had the lowest detection rate. All 3 major Shigella were resistant to 11 antibiotics. The resistance rate against ampicillin, ampicillin sulbactam, ciprofloxacin, gentamicin was relatively higher. The sensitivity rate against ertapenem, imipenem, piperacillin tazobactam, ceftazidime were relatively higher. All 3 major Shigella were sensitive to piperacillin tazobactam, accounting for 100%. The drug resistance was identical in recent years. The number of cases resistant to ampicillin sulbactam, gentamicin and tobramycin increased year by year, S. sonnei and S. boydii were resistant to less antibiotics than S. flexneri. Conclusions The drug resistance of pathogenic bacteria in children with acute bacterial dysentery is unfavorable. The pathogen culture and drug resistance monitoring of acute bacterial dysentery in children should strengthen to propose reasonable application of antibiotics and control the evolution and progression of drug resistant pathogens. |