| Objective To analyze the epidemiological characteristics, clinical manifestations, laboratory tests, imaging features and clinical outcomes of patients with novel coronavirus disease-2019 (COVID-19), and provide reference for the diagnosis and treatment of COVID-19. Methods Thirty-nine COVID-19 patients with positive results in SARS-CoV-2 nucleic acid test were enrolled from the Second People’s Hospital of Chenzhou City from January 21, 2020 to February 24, 2020. Their epidemiological characteristics, initial symptoms, WBC, lymphocyte count, procalcitonin (PCT), IL-6, CRP, CD4+ T lymphocyte count, CD8+ T lymphocyte count, imaging data and clinical outcome were analyzed. Results Among the 39 patients, there were 2 mild cases, 35 common cases and 2 severe cases. With the exception of those patients with no definite contact history or having the onset prior to their return, the incubation period was 2.0-12.0 days with a mean of (7.7 ± 3.3) days, 32 cases (82.05%) had a history of sojourn or contact in Wuhan before the onset of the disease, 5 cases (12.82%) had a history of sojourn or contact in Guangdong before the onset of the disease, and 2 cases (5.12%) had no clear suspected contact history. There were 7 familial aggregation, 26 patients in total, accounting for 66.67% of the total patients. Twenty-four patients (61.54%) had fever in the early stage, 25 patients (64.10%) had cough in the early stage, a few patients had pharyngeal pain, muscle soreness, anorexia, cough and diarrhea, and 3 patients (7.69%) had no clinical manifestations. WBC decreased in 12 cases (30.77%). Lymphocyte count decreased in 8 cases (20.51%). T cell count decreased in 3 cases (7.69%). ALT increased in 12 cases (30.77%). TBIL increased in 10 cases (25.64%). LDH increased in 21 cases (53.85%); CRP elevated in 18 cases (46.15%); IL-6 elevated in 3 cases (7.69%); and all patients had normal PCT. CT findings of the lung showed multiple lesions in both lungs, mainly in the lateral subpleural zone, with patchy and cloud flocculent ground glass changes. Six patients with common COVID-19 were followed up after discharge. The lung lesions were completely absorbed for 18.0-31.0 days, with an average of (26.8±4.5) days. Conclusions In this study, COVID-19 patients in the early stage are imported cases, those in the advanced stage are family clustering cases. Fever and cough are common symptoms in the clinical manifestations. A few patients are mild or even asymptomatic. Most of the patients are common cases. Patchy, cloud flocculent ground glass changes are predominant by chest CT findings. The improvement of lung lesions is not completely synchronized with the negative transformation of nucleic acid. At present, the prognosis of common COVID-19 patients is good during follow-ups. |