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| 滤泡调节性T细胞与HIV感染疾病进展关系的研究 |
| Relationship between follicular regulatory T cells and HIV infection progression |
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| DOI：10.3969/j.issn.1007-8134.2020.04.010 |
| 中文关键词: 人免疫缺陷病毒 滤泡调节性T细胞 CD4+ T细胞 病毒载量 |
| 英文关键词: HIV follicular regulatory T cell CD4+ T cell viral load |
| 基金项目:“十三五”国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（2018ZX10301407-005，2018ZX10302103-001-003）；艾滋病研究北京市重点实验室（BZ0089） |
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| 中文摘要: |
| 目的 探索滤泡调节性T细胞（follicular regulatory T cell, TFR）与HIV感染疾病进展的关系。方法 以2015—2019年于首都医科大学附属北京佑安医院门诊就诊及随访的47例HIV感染者（包括未治疗HIV感染者，抗病毒治疗免疫重建成功和免疫重建失败患者）及9例健康体检者作为研究对象。将CD3+CD4+CXCR5+Foxp3+的细胞定义为TFR，分析HIV感染者TFR数量与CD4+ T细胞计数及病毒载量的关系，并对比分析不同疾病阶段患者TFR数量的差异。结果 TFR数量与CD4+ T细胞计数呈正相关（r=0.567，P=0.002），与HIV载量呈负相关（r=-0.394，P=0.042）；HIV感染者的TFR数量明显低于健康体检者，免疫重建成功的患者TFR数量明显高于免疫重建失败的患者。结论 随着HIV感染疾病的进展，TFR数量逐渐降低。 |
| 英文摘要: |
| Objective To explore the relationship between follicular regulatory T cells (TFR) and the progression of HIV infection. Methods A total of 47 HIV-infected patients (including untreated HIV-infected patients, patients with successful immune reconstruction, patients with unsuccessful immune reconstruction after antiretroviral therapy) who were treated and followed up at Beijing YouAn Hospital, Capital Medical University from 2015 to 2019 and 9 healthy physical examinees were enrolled in this study. The CD3+CD4+CXCR5+Foxp3+ cells were defined as TFR. The relationship of the absolute number of TFR with the CD4+ T cell count and viral load of HIV-infected patients was analyzed, and the differences in the number of TFR at different disease stages were compared and analyzed. Results The TFR count was positively correlated with CD4+ T cell count (r=0.567, P=0.002), and negatively correlated with HIV viral load (r=-0.394, P=0.042); TFR levels of HIV-infected patients were significantly lower than that of healthy physical examinees. Patients with successful immune reconstruction had a significantly higher TFR level than patients with unsuccessful immune reconstruction. Conclusions As HIV infection progresses, TFR level gradually decreases. |
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