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| 124例AIDS相关恶性淋巴瘤临床特点及预后分析 |
| Clinical characteristics and prognosis analysis of 124 cases with AIDS-related lymphoma |
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| DOI：10.3969/j.issn.1007-8134.2020.04.011 |
| 中文关键词: 获得性免疫缺陷综合征 淋巴瘤 临床特点 化疗 |
| 英文关键词: acquired immunodeficiency syndrome lymphoma clinical characteristic chemotherapy |
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| 中文摘要: |
| 目的 总结云南省传染病医院/艾滋病关爱中心2008年1月—2017年6月收治的124例AIDS相关恶性淋巴瘤（AIDS-related lymphoma, ARL）患者的临床特点及预后。方法 回顾性分析124例ARL患者的临床资料。结果 124例ARL患者中，男女比例为4.63∶1，中青年较多，合并丙型肝炎者占13.71%。有非霍奇金淋巴瘤（non-Hodgkin lymphoma, NHL）121例（97.58%），霍奇金淋巴瘤（Hodgkin lymphoma, HL）3例（2.42%）。121例NHL中，B型细胞淋巴瘤112例（92.56%），T型细胞淋巴瘤9例（7.44%）。124例ARL患者中，87例淋巴瘤原发于结内，有61例出现淋巴瘤B症状。CD4+ T淋巴细胞计数＜200个/μl者110例，≥200个/μl者14例。未接受治疗者25例，接受治疗者99例，未接受治疗者生存期为10 d～11个月，接受治疗者生存期为5年的有17例。结论 ARL患者的临床表现多样，免疫力低下。ARL恶性程度高，并发症多，治疗难度大。了解ARL的特点，有利于早发现，早诊断，综合治疗，提高生存率。 |
| 英文摘要: |
| Objective To summarize the clinical characteristics and prognosis of 124 patients with AIDS-related lymphoma (ARL) in Yunnan Provincial Infectious Disease Hospital/Yunnan AIDS Care Center from January 2008 to June 2017. Methods Clinical information of 124 ARL cases were retrospectively analyzed. Results Among the 124 ARL patients, the male-to-female ratio was 4.63∶1, and most of them were young and middle-aged, and 13.71% of cases had a complication of hepatitis C; There were 121 cases (97.58%) of non-Hodgkin lymphoma (NHL) and 3 cases (2.42%) of Hodgkin lymphoma (HL). Among 121 NHL patients, 112 cases (92.56%) were B-cell lymphoma and 9 cases (7.44%) were T-cell lymphoma, 87 cases of lymphoma originated in node, 61 cases presented lymphoma B symptoms. CD4+ T lymphocyte count was ＜200 cells/μl in 110 cases, and ≥200 cells/μl in 14 cases. Twenty-five cases were untreated and their survival time was from 10 days to 11 months, while 99 cases were treated and 17 of them had a 5-year survival time. Conclusions ARL patients have diverse clinical manifestations and hypoimmunity. ARL is highly malignant, induces several complications, and is difficult to cure. Understanding the characteristics of ARL is conducive to early detection, early diagnosis, comprehensive treatment and improve survival rate. |
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