石家庄地区45例COVID-19患者临床特征分析

王德华; 郑欢伟; 王建民; 封丽琴; 卢伟娜; 董金红; 戴二黑

文章摘要

石家庄地区45例COVID-19患者临床特征分析

Analysis of clinical characteristics of 45 COVID-19 patients in Shijiazhuang

DOI：10.3969/j.issn.1007-8134.2020.05.007

中文关键词: 新型冠状病毒肺炎流行病学临床特征氨溴索预后

英文关键词: COVID-19 epidemiology clinical characteristic ambroxol prognosis

基金项目:石家庄市新型冠状病毒肺炎防控应急科研攻关项目（201460513A-3）

作者	单位
王德华	石家庄市第五医院介入医学科
郑欢伟	石家庄市第五医院肝病研究所
王建民	石家庄市第五医院介入医学科
封丽琴	石家庄市第五医院重症监护室
卢伟娜	石家庄市第五医院肝病科
董金红	石家庄市第五医院介入医学科
戴二黑	石家庄市第五医院肝病研究所

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中文摘要:

目的　分析石家庄地区45例新型冠状病毒肺炎（coronavirus diseases-2019, COVID-19）患者的流行病学特征、临床表现、治疗及预后情况，为COVID-19的防治提供参考。方法　收集2020年1月21 日—5月31日在石家庄市第五医院就诊的45例COVID-19患者临床信息，根据临床表现将患者分为无症状/轻型组，普通型组，重/危重型组，对比分析不同组间临床症状、实验室与影像学检查、治疗及预后情况。结果　45例患者中，聚集性感染病例占57.78%；临床症状以发热、咳嗽/咳痰为主，重/危重型组患者发热比例更高；此外，患者年龄方面，重/危重型组明显高于其他2组（P＜0.05）；部分患者出现WBC、淋巴细胞计数下降，CRP升高及肝功能异常。其中3组之间淋巴细胞计数比较差异有统计学意义，两两比较，重/危重型组患者淋巴细胞计数显著低于无症状/轻型组（P＜0.05）。3组之间CRP比较差异亦有统计学意义，两两比较，差异均有统计学意义（P均＜0.05）。肺CT病变主要以双肺多发为主，多表现为磨玻璃样渗出。出院患者2周后复查核酸，7例患者核酸检测阳性。结论　石家庄地区COVID-19患者临床特征与其他地区相似，但病例以聚集性为主，当地COVID-19疫情防控工作须持续加强，同时应重点强化中老年患者的防护与救治，并注意出院患者的随访观察。

英文摘要:

Objective　To analyze the epidemiological characteristics, clinical manifestations, treatment and prognosis of 45 patients with coronavirus diseases-2019 (COVID-19) in Shijiazhuang region, and to provide reference for COVID-19 prevention and treatment. Methods　The clinical data of 45 COVID-19 patients in the Fifth Hospital of Shijiazhuang from January 21 to May 31, 2020 were collected. According to the clinical manifestations, the enrolled patients were divided into asymptomatic/mild group, common group and severe/critical group. The clinical symptoms, laboratory and imaging examination, treatment and prognosis of different groups were compared and analyzed. Results　Among the 45 patients, 57.78% cases had cluster infection. The main clinical symptoms were fever and cough/expectoration. The incidence of fever was higher in the severe/critical group. In addition, the age of patients in the severe/critical group was significantly higher than that in the other 2 groups (P＜0.05). Some patients had decreased WBC and lymphocyte count, increased CRP and abnormal liver function. Lymphocyte count showed statistically significant differences in 3 groups. By multiple comparison, the lymphocyte count in the severe/critical group was significantly lower than that in asymptomatic/mild group (P＜0.05). CRP also showed statistically significant differences in 3 groups. By multiple comparison, the difference was statistically significance (P＜0.05). Multiple lung CT lesions were prevalent in both lungs, represented by ground glass exudation. All patients were rechecked for nucleic acid at 2 weeks after discharge and 7 patients were tested positive for nucleic acid. Conclusions　The clinical characteristics of COVID-19 patients in Shijiazhuang region are similar to those in other regions, but the affected cases are mainly clustered. Local COVID-19 epidemic prevention and control work should continue to be strengthened and focus on the protection and treatment of middle-aged and elderly patients, and monitor follow-up observations of discharged patients.

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