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| 云南省AIDS相关淋巴瘤患者死亡因素分析 |
| Analysis of death causes of AIDS-related lymphoma in Yunnan Province |
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| DOI：10.3969/j.issn.1007-8134.2020.06.006 |
| 中文关键词: 艾滋病 恶性淋巴瘤 死亡原因分析 |
| 英文关键词: AIDS malignant lymphoma death cause analysis |
| 基金项目:国家“十三五”科技重大专项（2018ZX10302104-002-002） |
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| 中文摘要: |
| 目的 探讨AIDS相关淋巴瘤患者的死亡因素，为降低病死率探索有效措施。方法 收集云南省传染病医院2010年10月—2019年4月收治的34例AIDS相关淋巴瘤死亡患者的临床资料，并分析死亡原因。结果 临床资料显示34例死亡病例表现为：高LDH水平，合并EBV感染率高，骨髓侵犯易见，常伴有分子生物学指标异常。导致其死亡的原因依次为：难治（70.6%）、感染（17.7%）、自杀（5.9%）、复发（2.9%）、第二肿瘤（2.9%）。结论 难治/复发是AIDS相关淋巴瘤患者的主要死亡原因，减少该类患者死亡除采取更为积极有效的治疗方法外，应建立以患者为中心的包括心理社会肿瘤学工作者在内的多学科团队，为患者制定最佳的个体化诊疗方案，才能切实降低病死率，提高生存质量。 |
| 英文摘要: |
| Objective To investigate the death causes in patients with AIDS-related lymphoma and explore effective measures to reduce mortality. Methods Clinical data of 34 dead patients with AIDS-related lymphoma from October 2010 to April 2018 in Yunnan Provincial Infectious Diseases Hospital were collected. The causes of death were analyzed. Results The clinical manifestations of 34 dead patients included high LDH level, high infection rate with EB virus, common bone marrow invasion and abnormal molecular biology. The causes of death in AIDS-related lymphoma patients were: refractory (70.6%), infection (17.7%), suicide (5.9%), recurrence (2.9%) and second tumor (2.9%) by turns. Conclusions Refractory condition /recurrence is the main cause of death in patients with AIDS-related lymphoma. In addition to adopting more active and effective treatment methods, a patient-centered multidisciplinary team including psychosocial oncologists should be established to formulate the optimal individualized diagnosis and treatment plan for patients, so as to effectively reduce the mortality of AIDS-related lymphoma and improve the quality of life ultimately. |
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