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| 维持性血液透析HIV/AIDS患者的认知功能调查 |
| Investigation of cognitive functions in maintenance hemodialysis patients with HIV/AIDS |
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| DOI：10.3969/j.issn.1007-8134.2020.06.008 |
| 中文关键词: HIV/AIDS 维持性血液透析 认知功能 高效抗反转录病毒治疗 影响因素 |
| 英文关键词: HIV/AIDS maintenance hemodialysis cognitive function highly active antiretroviral therapy influential factor |
| 基金项目:广西壮族自治区卫生健康委员会计划项目（Z2016812） |
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| 中文摘要: |
| 目的 评估维持性血液透析（maintenance hemodialysis, MHD）HIV/AIDS患者认知功能，分析其相关影响因素。 方法 收集2014年1月—2018年12月南宁市第四人民医院MHD 3个月及以上且合并HIV 感染的73例患者的临床资料，以国际人类免疫缺陷病毒相关性痴呆量表评分评估MHD HIV/AIDS患者认知功能，根据有无认知功能障碍分为正常组及认知功能障碍组，分析其可能影响因素。结果 73例MHD HIV/AIDS患者中，认知功能障碍发病率为83.56%。认知功能障碍组年龄、透析龄均高于正常组（P均＜0.05 ）；受教育年限、高效抗反转录病毒治疗（highly active antiretroviral therapy, HAART）时程、CD4+ T淋巴细胞计数基线、尿素清除指数（Kt/V）均低于正常组（P均＜0.05 ）。结论 MHD HIV/AIDS患者具有较高的认知功能障碍发病率，年龄、透析龄、受教育年限、HAART时程、CD4+ T淋巴细胞计数基线、Kt/V是其可能影响因素。 |
| 英文摘要: |
| Objective To evaluate the cognitive function and analyze the influential factors in maintenance hemodialysis (MHD) patients with HIV/AIDS. Methods Clinical data of 73 patients with MHD for 3 months and longer complicated by HIV infection were collected from the Fourth People’s Hospital of Nanning from January 2014 to December 2018. International HIV-associated dementia scale score was used to evaluate cognitive function in MHD patients with HIV/AIDS. They were divided into normal group and cognitive dysfunction group according to the presence or absence of cognitive dysfunction, and the possible influencing factors were analyzed. Results A total of 73 MHD patients with HIV/AIDS were enrolled, and the prevalence of cognitive dysfunction was 83.56%. Compared with the normal group, the age and hemodialysis duration in the cognitive dysfunction group were higher (P＜ 0.05). The education duration, highly active antiretroviral therapy (HAART) time, baseline CD4+ T lymphocyte count and urea clearance index (Kt/V) were lower (P＜0.05). Conclusions MHD patients with HIV/AIDS have a higher incidence of cognitive dysfunction. Age, hemodialysis duration, education duration, HAART time, baseline CD4+ T lymphocyte count and Kt/V are the possible influencing factors. |
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