文章摘要
肝吸虫感染致胆管损伤及胆管癌的相关研究进展
Research progress on bile duct injury and cholangiocarcinoma caused by liver fluke infection
  
DOI:10.3969/j.issn.1007-8134.2022.02.015
中文关键词: 肝吸虫  胆管癌  机械刺激  排泄分泌物  免疫反应  胆汁淤积  肠道菌群  肠肝循环
英文关键词: liver fluke  cholangiocarcinoma  mechanical stimulation  excretory-secretory product  immune response  cholestasis  intestinal flora  enterohepatic circulation
基金项目:江苏省自然科学基金项目(BK20201011);江苏省高等学校自然科学研究项目(20KJB310011);江苏省博士后基金项目(RC7062005)
作者单位
张蓓蓓 徐州医科大学病原生物学与免疫学教研室 
陈泽斌 广州中山大学第一附属医院肝胆外科 
吴晓瑛 广州中山大学第三附属医院消化内科 
郑葵阳 徐州江苏省免疫与代谢重点实验室 
吴忠道 广州中山大学中山医学院寄生虫学教研室 
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中文摘要:
      [摘要] 肝吸虫是一种重要的食源性寄生虫,包括华支睾吸虫、后睾吸虫和肝片吸虫等,其成虫寄生在肝胆管或胆管内,可引起以肝胆管损伤为主要病变的肝脏疾病。肝吸虫已被WHO明确列为胆管癌的I类致癌物。在我国广泛流行的主要是华支睾吸虫,因此本文将以华支睾吸虫为例,结合最新研究进展,分别从虫体(虫体机械刺激和排泄分泌物毒性损伤作用)和宿主(免疫应答反应、胆汁淤积、肠肝循环障碍、肠道菌群失衡等)两方面系统阐述肝吸虫感染致胆管系统病变以及胆管癌发生发展的致病机制。
英文摘要:
      [Abstract] Liver fluke including Clonorchis sinensis, Opisthorchis, and Fasciola hepatica, is one of the important food-borne parasites. The adult worms of liver fluke dwell in the hepatobiliary bile duct and therefore induce hepatic bile duct injury as the main pathological change. Liver fluke has been classified as a class one carcinogen of cholangiocarcinoma by the WHO. As Clonorchis sinensisis is widely prevalent in China, this review will summarize the latest progress on the pathogenesis of biliary system injury, and the occurrence and development of cholangiocarcinoma induced by Clonorchis sinensis infection. It will be discussed from two perspectives: the first one is from the worm viewpoint (mechanical stimulation and toxic damage of excretory-secretory products) and the second, from the host (immune response, cholestasis, enterohepatic circulation disorder, and intestinal flora imbalance).
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