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| 汉坦病毒感染致血小板减少的机制 |
| Relationship between plasma miR-159 level and |
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| DOI：10.3969/j.issn.1007-8134.2021.01.016 |
| 中文关键词: 血小板减少 汉坦病毒 肾综合征出血热 |
| 英文关键词: infectious mononucleosis children microRNA-155 EBV DNA load correlation active period remission period predictive value |
| 基金项目:国家自然科学基金面上项目（81373118）；陕西省自然科学基金一般项目（2020SF-102） |
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| 中文摘要: |
| 汉坦病毒主要感染血管内皮细胞，引起两种人类疾病，即肾综合征出血热和汉坦病毒心肺综合征，它们的共同特点是毛细血管广泛损伤，通透性升高。汉坦病毒感染者血小板数量严重减少，不仅与“外周破坏增加”有关，而且还可能与“血小板生成和功能障碍”有关。尽管汉坦病毒感染引起血小板减少的机制尚不完全明确，但近年也取得了一些重要进展。本文主要围绕血小板减少相关的两种机制展开讨论，旨在阐明汉坦病毒感染发病机制，为治疗肾综合征出血热的药物设计提供指导。 |
| 英文摘要: |
| Hantavirus mainly infects vascular endothelial cells and causes 2 human diseases, namely hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. All hantavirus-associated diseases are characterized by extensive damage to the capillary and increased permeability. In patients infected with hantavirus, there is a dramatic decrease in platelet count, which is associated with “increased peripheral destruction” and also “thrombopoiesis and dysfunction”. Although the mechanism by which hantavirus infection causes thrombocytopenia remains unclear, important advances have been made in recent years. This review focuses on 2 mechanisms related to thrombocytopenia, aiming to clarify the pathogenesis of hantavirus infection and provide guidance for drug design in the treatment of hemorrhagic fever with renal syndrome. |
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