| Objective To?explore?the?omics?mechanism?of?cidofovir?in?the?treatment?of?COVID-19. Methods The R language was used to analyze the difference, enrichment and protein interaction of cidofovir related genome-wide expression profiles in the gene expression omnibus (GEO) database, and the self-developed epigenomic precision medicine (EpiMed) prediction platform was used to filter the diseases and drugs associated with cidofovir. Results GSE39293?data sets?were?retrieved?and?filtered?in?GEO?database.?Total?of?585?differentially?expressed?genes?were?screened?by?differential?expression analysis,?among?which?494?genes?were?up-regulated?and?91?genes?were?down-regulated. There?were?53?gene ontology enrichment?items,?which?were?mainly?related?to?interfering with virus replication, type I interferon action and immune regulation. There?were?244?kyoto encyclopedia of genes and genomes?enrichment?items,?which?were?mainly?related?to?antivirus,?anti-apoptosis,?immune?regulation?and coagulation?system related signal pathways. CDK1, CCNA2, CDC6, KIF11, MAD2L1, NDC80, RRM2, ASPM, NCAPG?and?CENPU?were?screened?as?the?top?10?core?genes?by?protein?interaction?network?analysis. EpiMed predicted?that?the?genome?expression?profile?regulated?by?cidofovir?was?negatively?correlated?with?diseases?such?as?pneumonia?and severe?acute?respiratory syndrome. It?was?positively?correlated?with?ribavirin and?alpha-interferon. It?was?negatively correlated?with?antibiotics?such?as?chlamycin and?norfloxacin. Conclusions Cidofovir can affect the whole genome of the organism and may reduce the number of SARS-COV-2 in vivo by inducing apoptosis of infected cells. Through immunoregulation and coagulation system related signaling pathways, the body’s immune disorders and coagulation dysfunction in severe patients can be regulated to achieve the effect of treating COVID-19. |