| Objective To explore the distribution and infection characteristics of sepsis pathogenic bacteria in patients with decompensated hepatitis B cirrhosis and analyze the drug resistance for common antibacterials. Methods A total of 490 patients with decompensated hepatitis B cirrhosis who were hospitalized in our hospital from March 2015 to December 2017 were selected as the study subjects. The pathogenic infection and drug sensitivity results were analyzed using automated blood culture system and K-B method. Results Among 490 patients, 51 cases were positive by pathogenic bacteria, with a positive rate of 10.41%. A total of 59 pathogenic bacterial strains were cultured, mainly Gram-negative bacteria, accounting for 72.88%, followed by Gram-positive bacteria, accounting for 22.03%; In patients with decompensated hepatitis B cirrhosis, the pathogenic bacteria of sepsis had a certain resistance to commonly used clinical antibacterial drugs. Among the Gram-negative bacteria, the highest resistance rate was observed in Stenotrophomonas maltophilia to ampicillin, accounting for 7/9; Among the Gram-positive bacteria, Staphylococcus aureus showed the highest resistance rate to penicillin, clindamycin and rifampicin, accounting for 2/3. Conclusions The pathogenic bacteria that cause sepsis in patients with decompensated hepatitis B cirrhosis are mainly Gram-negative bacteria, which are resistant to commonly used antibacterial drugs in clinical practice. For sepsis patients with decompensated hepatitis B cirrhosis, the pathogenic bacteria for nosocomial infections and drug resistance should be monitored dynamically, and reasonable antibacterial treatment should be selected based on the results of drug sensitivity. |