| Objective To understand the distribution and resistance characteristic of carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital, and provide evidence for clinically efficient prevention and treatment of CRKP. Methods CRKP were isolated from the submitted specimens of inpatients in the First Affiliated Hospital of Wannan Medical College from January 2016 to December 2018. The strain identification and drug susceptibility testing were conducted. The specimen types, department distribution and resistance to antimicrobial agents of CRKP strains were analyzed. Results Totally 159 CRKP strains by non-repeated isolation were collected from 2106 to 2018, the detection rate of CRKP decreased from 12.20% in 2016 to 4.56% in 2018, showing an annual downward trend (χ2trend=31.198, P=0.000). Most CRKP strains were harvested from sputum (n=119, 74.84%). The top 3 departments with a high detection rate were department of neurosurgery (including neurosurgery ICU; 22.01%, 35/159), department of respiratory medicine (including respiratory medicine ICU; 18.87%, 30/159) and ICU (including emergency ICU; 15.09%, 24/159). CRKP strains were generally resistant to antimicrobial agents, including penicillins, cephalosporins and quinolones, accounting for a resistance rate of＞80%. The resistance rates of CRKP in the department of respiratory medicine (including respiratory medicine ICU) were higher than those in other departments, except compound sulfamethoxazole and nitrofurantoin. Conclusions The detection rate of CRKP is annually decreasing. The prevention and control measure of CRKP play a significant role. However, CRKP still has severe resistance, which still deserves continuous close attention. |