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| 儿童多系统炎症综合征研究进展 |
| Research progress in multisystem inflammatory syndrome in children |
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| DOI：10.3969/j.issn.1007-8134.2021.04.002 |
| 中文关键词: 儿童多系统炎症综合征 2019新型冠状病毒病 儿童 川崎病 |
| 英文关键词: multisystem inflammatory syndrome in children coronavirus disease 2019 children Kawasaki disease |
| 基金项目:西北妇女儿童医院院内重点科研项目（Z201301） |
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| 中文摘要: |
| 儿童多系统炎症综合征（multisystem inflammatory syndrome in children, MIS-C）是一种以发热、消化道症状、心脏损害及休克等多系统受累为特征的疾病，伴炎症及心肌损伤标志物明显升高，同时存在严重急性呼吸综合征冠状病毒-2（severe acute respiratory syndrome-associated coronavirus, SARS-CoV-2）感染证据或2019新型冠状病毒病（coronavirus disease 2019, COVID-19）接触史。MIS-C的发病机制尚未明确，可能与SARS-CoV-2感染后继发的免疫失调有关，目前多在欧美国家报道。MIS-C与川崎病临床表现相似，主要不同是该病与SARS-CoV-2感染相关。60%的MIS-C患儿需要重症监护，大多接受抗炎和免疫调节为主的综合治疗，病死率为0.9%～2.0%。目前全球COVID-19疫情防控仍面临严峻挑战，儿科医生应提高识别MIS-C的能力。 |
| 英文摘要: |
| Multisystem inflammatory syndrome in children (MIS-C) is a disease involving multiple systems, characterized by fever, gastrointestinal symptoms, cardiac damage and shock, accompanied by significantly increased markers of inflammation and myocardial injury. The evidence of severe acute respiratory syndrome-associated coronavirus (SARS-CoV-2) infection or coronavirus disease 2019 (COVID-19) exposure history coexisted. The pathogenesis of MIS-C is not clear yet, and it may be related to immune disorders secondary to novel coronavirus infection, which has been reported mostly in European and American countries at present. The clinical manifestations of MIS-C are similar to those of Kawasaki disease, with the main difference being associated with SARS-CoV-2 infection. Among MIS-C patients, 60% require intensive care and most receive anti-inflammatory and immunomodulatory-dominant combined therapy, with a fatality rate of 0.9%-2.0%. At present, the global prevention and control of COVID-19 is still facing severe challenge. Pediatricians should improve their ability to identify MIS-C. |
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