| Objective To observe the effect of calcium and zinc gluconate oral liquid combined with Saccharomyces boulardii sachets on symptom control and gastrointestinal function in children with rotavirus infection, and to provide reference for clinical treatment. Methods From August 2017 to October 2019, 120 children with rotavirus infection were selected from Sanya People’s Hospital, as the study subjects. According to the treatment methods, they were divided into conventional group and combined group, with 60 cases in each. The conventional group was treated with diet guidance, reasonable fluid rehydration, antiviral therapy and electrolyte disturbance prevention or correction therapy. The combined group was treated with calcium and zinc gluconate oral liquid combined with Saccharomyces boulardii sachets, in addition to conventional treatment in conventional group. The changes of intestinal flora content and serum levels of gastrointestinal hormones in fecal samples before and after treatment were recorded, and the overall response rate, symptom improvement time (antipyretic, anti-diarrhea, anti-vomiting, normal stool traits) and hospitalization time of children in 2 groups were statistically analyzed. Results After treatment, the overall response rate of the combined group was 93.33%, which was higher than that of the conventional group 80.00% (P＜0.05). The antipyretic time [(1.69±0.42) d], anti-diarrhea time [(2.28±0.45) d], anti-vomiting time [(1.92±0.44) d], time to restore normal stool traits [(2.30±0.45) d], hospitalization time [(4.82±1.37) d] in the combined group were shorter than those in the conventional group, and the difference was statistically significant (P＜0.05). Before treatment, there was no significant difference in intestinal flora content and serum levels of gastrointestinal hormones in fecal samples between 2 groups (P＞0.05). After treatment, the contents of bifidobacteria and lactobacilli in the fecal samples of 2 groups increased compared with those before treatment, and the contents of enterobacteria and serum gastrin, motilin, and vascularly active intestinal peptides decreased compared with those before treatment, and the improvement of intestinal flora content in fecal samples and the decline of gastrointestinal hormones of the combined group were greater than that of the conventional group (P＜0.05). Conclusions Calcium and zinc gluconate oral liquid combined with Saccharomyces boulardii sachets can promote the disappearance of clinical symptoms, improve the level of gastrointestinal hormone, balance intestinal flora and improve the curative effect in children with rotavirus infection. |