| Objective To observe the clinical effect of ribavirin combined with Qingrejiedu Recipe in treating epidemic parotitis children with pattern of heat-toxin congestion and excessiveness, and to explore its effects on serum amyloid A protein (SAA) and amylase. Methods From April 2016 to September 2019, 82 children with epidemic parotitis in our hospital were selected as the research objects. They were divided into observation group and control group by using random number method, with 41 cases in each group. The control group was treated with ribavirin, and the observation group was given Qingrejiedu Recipe on the base of the control group. The extinction time of symptoms and signs (fever, parotid gland swelling, gland pain), length of hospital stay, clinical curative effect, adverse reaction, the levels of SAA and amylase of children in 2 groups were compared. Results The extinction time of symptoms and the length of hospital stay of the observation group were significantly shorter than those of the control group (P＜0.05). The overall response rates of symptom relief in observation group and control group were 95.12% and 80.49%, respectively, and the rate in observation group was significantly higher than that in control group (P＜0.05). After treatment, SAA, total amylase and salivary amylase levels of children in 2 groups were significantly declined, and the decline in the observation group was significantly higher than that in the control group. The differences were statistically significant (P＜0.05). The incidences of adverse reactions in observation group and control group were 7.32% and 9.76%, respectively, without significant difference (P＞0.05). Conclusions Ribavirin combined with Qingrejiedu Recipe can reduce the levels of SAA and amylase, improve the swelling and pain of parotid gland, alleviate clinical symptoms and shorten the treatment time in children with epidemic parotitis with pattern of heat-toxin congestion and excessiveness, which is worthy of clinical promotion. |