| Hepatic fibrosis refers to the diffused and excessive deposition of liver extracellular matrix. It is a repair response of the body to liver parenchymal damage and a common pathological process of many chronic liver diseases, and it is also an important step for the development of various chronic liver diseases to cirrhosis. So far, there is no specific and effective drug to effectively reverse or prevent the progress of hepatic fibrosis, and an early diagnosis of hepatic fibrosis is of great significance. The diagnosis of hepatic fibrosis mainly relies on histopathology, serological markers and imaging methods. Liver biopsy is considered to be the gold standard for the diagnosis and staging of hepatic fibrosis. In recent years, due to the risks and limitations of liver biopsy, the establishment of a non-invasive hepatic fibrosis evaluation model has become a scientific problem that needs to be solved urgently in clinical practice and research hotspot. This article reviews the research progress of non-invasive serological detection of hepatic fibrosis within recent years, and provides a reference for the diagnosis of hepatic fibrosis. |