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| 单纯疱疹病毒性角膜炎治疗方法研究进展 |
| Research progress in herpes simplex keratitis treatment |
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| DOI：10.3969/j.issn.1007-8134.2021.04.019 |
| 中文关键词: 单纯疱疹病毒1型 单纯疱疹病毒性角膜炎 治疗 综述 |
| 英文关键词: herpes simplex virus 1 herpes simplex keratitis therapy review |
| 基金项目:辽宁省自然科学基金（20180551129）；科学研究经费项目-青年科技人才“育苗”项目（辽教办[2019]117号-SJ201910） |
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| 中文摘要: |
| 单纯疱疹病毒1型（herpes simplex virus 1, HSV-1）是一种普遍存在的病原体，感染角膜可引起单纯疱疹病毒性角膜炎（herpes simplex keratitis, HSK）。HSV-1可潜伏于三叉神经胞体，易形成复发感染。多次反复恶化可造成角膜免疫-炎症反应损伤，促进新生血管形成，进一步导致角膜浑浊、视力障碍甚至失明，是导致角膜盲的首要病因之一。目前，临床使用的抗病毒药物不能根除HSV-1，本文将汇总有关HSK的最新治疗进展，主要从抑制HSV-1入侵、增殖以及减少新血管生成两方面进行综述，以期为临床研究提供理论依据。 |
| 英文摘要: |
| Herpes simplex virus 1 (HSV-1) is a common pathogen that can cause herpes simplex keratitis (HSK) when it infects the cornea. HSV-1 can be latent in the trigeminal nerve cell soma, and easily form recurrent infection. Repeated deterioration causes corneal immune-inflammatory response injury, promotes the formation of new blood vessels, and further leads to corneal opacity, visual impairment and even blindness, which is one of the primary causes of corneal blindness. At present, antiviral drugs used in clinical practice cannot eradicate the HSV-1. This paper summarizes the latest progress in the treatment of HSK, and reviews the inhibition of virus invasion and proliferation and the reduction of new blood vessel formation, in order to provide theoretical basis for clinical research. |
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