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| 快速血浆反应素滴度与神经梅毒相关性的Meta分析 |
| Meta-analysis on the correlation between rapid plasma reagin titre and neurosyphilis |
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| DOI：10.3969/j.issn.1007-8134.2021.05.004 |
| 中文关键词: 梅毒 神经梅毒 快速血浆反应素 Meta分析 |
| 英文关键词: syphilis neurosyphilis rapid plasma reagin Meta-analysis |
| 基金项目:“十三五”国家科技重大专项（2017ZX10201101）；北京市优秀人才计划（2018000021223ZK04） |
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| 中文摘要: |
| 目的 系统评价梅毒患者血快速血浆反应素（rapid plasma regain, RPR）滴度≥1∶32与神经梅毒（neurosyphilis, NS）的相关性。方法 检索公开发表的有关血RPR滴度≥1∶32与NS相关性的观察性研究，对纳入的研究进行数据提取并质量评价，采用RevMan 5.4软件进行Meta分析。结果 纳入14篇文献共16项研究，NS患者1213例。Meta分析结果显示，血RPR滴度≥1∶32的梅毒患者发生NS的风险是血RPR滴度＜1∶32梅毒患者的3.99倍（OR=3.99，95%CI：2.95～5.41，P＜0.00001）。结论 血RPR滴度≥1∶32与NS之间具有一定相关性，是NS发生的危险因素，但不宜仅依据此作为梅毒患者进行腰椎穿刺的指征。 |
| 英文摘要: |
| Objective To systematically assess the correlation between rapid plasma reagin (RPR) titre≥1∶32 and neurosyphilis (NS) in syphilis patients. Methods The published observational studies on the correlation between RPR titre≥1∶32 and NS were searched. The data of the included studies were extracted, and the quality was evaluated. RevMan 5.4 software was used for meta-analysis. Results Fourteen articles involving 16 studies were included, including 1213 patients with NS. Meta-analysis showed that the risk of NS in syphilis patients with RPR titre≥1∶32 was 3.99 times higher than that in syphilis patients with RPR titre＜1∶32 (OR=3.99, 95%CI: 2.95-5.41, P＜0.00001). Conclusions There is a certain correlation between RPR titre ≥1∶32 and NS, which is a risk factor for NS. But it is inappropriate to rely solely on it as an indication for lumbar puncture in patients with syphilis. |
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