| Objective To investigate and analyze the infection characteristics and risk factors of refractory mycoplasma penumonia (MPP) in children. Methods One hundred and ninety-three MPP children who were treated in our hospital from August 2016 to August 2019 were selected. After unified treatment intervention, the incidence of refractory MPP was counted and the infection characteristics were discussed. The children were divided into refractory group and non-refractory group according to the disease progression. The basic data and clinical data of children in 2 groups were compared and analyzed. The risk factors of refractory MPP in children were analyzed by univariate analysis and multivariate Logistic regression analysis. Results Among 193 MPP patients, 78 patients had refractory MPP, accounting for an incidence of 40.41%. Clinical symptoms and manifestations of refractory MPP children included cough, fever, moist rales in lungs and punctate blurred shadows on chest X-ray. Laboratory examination showed that CRP and CK-MB levels were significantly increased. Univariate analysis showed that the difference was statistically significant between 2 groups of patients in the age, history of epidemic exposure, invasive operation, season of onset, antibiotic application, co-infection and coagulation status ( P＜0.05). Further multivariate Logistic regression analysis showed that younger age, history of epidemic exposure, invasive operation history, autumn and winter seasons, unreasonable use of antibiotics, co-infection and coagulation status were the high risk factors for refractory MPP. Conclusions Refractory MPP is characterized by persistent high fever, cough and moist rale in the lungs. Independent risk factors induced by refractory MPP include younger age, history of epidemic exposure, invasive operation, autumn and winter seasons, unreasonable use of antibiotics, co-infection and coagulation status. Great attention should be paid to them in clinical diagnosis and treatment. |