| Scrub typhus is a mite-borne fatal disease of natural focus caused by Orientia tsutsugamushi infection. The clinical manifestations are mainly fever, eschar or ulcer, enlarged lymph nodes and skin rash. It is endemic to East Asia and Southeast Asia regions. Atypical clinical symptoms often lead to misdiagnosis and missed diagnosis of scrub typhus. The rapid and accurate laboratory diagnosis plays the significantly crucial role on the confirmation and treatment of scrub typhus. This article reviewes the common methods of laboratory diagnosis for scrub typhus and the research advanced recent years. |