| To investigate the effect of interleukin-6 (IL-6) on the number and function of CXCR5+CD8+ T cells, that is follicular cytotoxic T cells (TFC) in HIV-infected patients. Methods Thirty-two HIV-infected patients who were not treated with anti-HIV therapy and were admitted to Hengyang Third People’s Hospital from October 2018 to December 2020 were enrolled. In the presence or absence of IL-6 stimulation for peripheral blood mononuclear cells and TFC, the difference regarding the number, function and apoptosis of TFC by in vitro culture were compared and analyzed. Results IL-6 stimulation could increase the number of TFC, enhance the function of TFC and reduce the apoptosis of TFC. Conclusions IL-6 can increase the number and enhance the function of TFC in HIV-infected patients. |