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| DOI： |
| 中文关键词: 肝硬化 肝肿瘤 超声 造影剂 微小肝癌 |
| 英文关键词: hepatic cirrhosis liver neoplasms ultrasonography contrast media micro hepatocellular carcinoma |
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| 摘要点击次数: 315 |
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| 中文摘要: |
| 超声造影不同灌注法诊断肝硬化微小肝癌的临床应用价值。方法 2015年2月—2017年5月本院收治的乙型肝炎肝硬化背景小肝癌患者65例，共71个病灶，诊断标准为经病理确诊或符合美国肝病研究协会（American Association for the Study of Liver Diseases, AASLD） 肝癌临床诊断标准。分别经外周静脉采用单次和双次灌注法注射造影剂，观察增强模式，研究不同造影方法检出微小肿瘤的敏感度。结果 71个病灶中，直径＜10 mm病灶29个，直径≥10 mm病灶46个，病灶 直径（17.47±7.19） mm。单次和双次灌注法对小肝癌检出敏感度分别为69.00%和94.37%，2种方法对直径＜10 mm病灶检出率差异具有统计学意义（P＜0.05），对直径≥10 mm病灶的检出率，差异不具有统计学意义（P＞0.05）。结论 超声造影可为小肝癌的诊断提供依据，作为MRI等影像诊断的互补手段，双次灌注超声造影法显著提高了小肝癌（尤其是直径＜10 mm 的微小肝癌）的检出率。 |
| 英文摘要: |
| o analyze the clinical application value of contrast-enhanced ultrasound (CEUS) with different perfusion methods on the diagnosis of micro hepatocellular carcinoma. Methods A total of 69 patients with small hepatocellular carcinoma in the context of hepatitis B cirrhosis who were admitted to our hospital from February 2015 to May 2017 were selected, involving 71 foci. The diagnostic criteria were based on the pathological conformation or comply with the clinical diagnostic criteria for hepatocellular carcinoma by the American Association for the Study of Liver Diseases (AASLD) [1]. The contrast media was injected via peripheral vein with single and double perfusion methods. The enhancement mode was observed. The sensitivity of different ultrasound methods to detect micro hepatocellular carcinoma was investigated. Results There were 29 foci at a diameter of ＜10 mm and 42 foci at a diameter of ≥10 mm. The minimal diameter of foci was 8 mm and maximal diameter was 30 mm, with an average diameter of (17.47±7.19) mm. The sensitivity of single and double perfusion methods to detect small hepatocellular carcinoma was 69.0% and 94.37%, respectively. The detection rate of＜ 10 mm foci by 2 methods showed statistical significance (P＜0.05), and that of≥10 mm foci was not statistically different (P＞0.05). Conclusions CEUS provides the evidence for the diagnosis of small hepatocellular carcinoma. As a complementary means of imaging diagnosis methods such as MRI, double-perfusion CEUS significantly increases the detection rate of small hepatocellular carcinoma (especially micro hepatocellular carcinoma at a diameter of ＜ 10 mm). |
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