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| PI3K/Akt信号通路在HIV感染中的研究进展 |
| Research progress on the PI3K / Akt signaling pathway in HIV infectioncharacteristics of asymptomatic carriers of COVID-19 |
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| DOI：10.3969/j.issn.1007-8134.2022.05.002 |
| 中文关键词: PI3K/Akt HIV 病毒储存库 T细胞 线粒体 HIV复制 HIV进入 免疫调节 |
| 英文关键词: |
| 基金项目:“十三五”国家科技重大专项（2017ZX10205501） |
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| 中文摘要: |
| [摘要] 磷脂酰肌醇3-激酶（phosphoinositide 3-kinase, PI3K）/蛋白激酶B（protein kinase B, PKB,普遍写作Akt）信号通路参与调控多种细胞功能，与多种疾病的发生密切相关。PI3K/Akt信号通路在HIV感染过程中也发挥重要作用，包括调节T细胞、线粒体功能，促进HIV复制，再激活潜伏HIV以及维持病毒储存库。因此，探索PI3K/Akt信号通路在HIV感染中的作用机制具有重要意义，针对PI3K/Akt的靶向治疗可能在抗HIV中发挥关键作用。本文对PI3K/Akt信号通路与HIV感染的相关研究进行综述，旨在为HIV的治疗提供新的思路与靶点。 |
| 英文摘要: |
| [Abstract] PI3K/Akt signaling pathway is involved in the regulation of cells function and is closely related to the occurrence of various diseases. Furthermore, PI3K/Akt signaling pathway plays a vital role in HIV infection, including regulating T cellsand mitochondrial function, promoting HIV replication, reactivating latent HIV, and maintaining virus reservoirs. Therefore, it is significant to explore the mechanism of PI3K/Akt signaling pathway in HIV infection. PI3K/Akt targeted therapy may play a key role in anti-HIV therapy. This review will integrate the correlative researches about PI3K/Akt signaling pathway in HIV infection aiming to provide new ideas and targets for the treatment of HIV infection. |
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