| [Abstract] Objective Preliminary exploration of the causal relationship between serum albumin levels and virus-negative conversion in long-term nucleic acid positive patients with corona virus disease 2019 (COVID-19). Methods?Patients hospitalized with mild COVID-19 of more than 30 days duration were enrolled, and their demographic information, treatment strategies, co-morbidities, laboratory examinations and other information were collected.Taking the cumulative negative rate of the virus within 45 days after the onset as the dependent variable, serum albumin level at 30±3 daysas the main analysis variable, and demographic information, treatment strategy, co-morbidities, laboratory tests and other informationas covariates.The effect of serum albumin level on the cumulative negative conversion rate was discussed by using the restricted cubic spline regression Cox proportional risk regression model. Results?A total of 189 patients were included in the analysis, of which 101 achieved virus-negative conversion within 45 days. Further analysis found a correlation between albumin levels at 30 days and the cumulative negative rate of virus at 45 days (P=0.027). When the albumin value is less than 39 g/L, low albumin level is a risk factor for virus negative, and the lower the albumin level, the higher the hazard ratio (Hazard ritio, HR).The closer the albumin value is to 39 g/L, the closerHR is to 1; When the albumin value is ≥39 g/L, the albumin level is no longer a risk factor for virus negative conversion. Conclusions?The level of serum albumin is closely related to viral negative conversion of COVID-19 patients. When the albumin value is＜39 g/L, the lower the albumin level, the less conducive to the negative conversion of the new coronavirus. Therefore, paying attention to the changes in albumin value during the treatment process and giving timely intervention may be beneficial toviral negative conversion of COVID-19 patients. |