| [Abstract] Objective To investigate the risk factors of carbapenem-resistant Klebsiella pneumonia (CRKP) bloodstream infection in hospitalized patients, and to construct a nomogram model. Methods?A total of 190 patients with bloodstream infection caused by Klebsiella pneumoniae (KP) admitted to the department of pharmacy of our hospital from January 1, 2016 to December 31, 2021 were selected as the research subjects. Accordingto the carbapenem resistance, they were divided into CRKP group (n=40) and carbapenem-sensitive Klebsiella pneumoniae (CSKP) group (n=150). Logistic regression model was used to analyze the risk factors of CRKP bloodstream infection in hospitalized patients, and a nomogram model for predicting CRKP bloodstream infection was drawn. ROC curve, calibration curve and Hosmer-Lemeshow (H-L) test are used to verify the nomogram model. Results?Indwelling urinary catheter, indwelling central venous catheter, use of immunosuppressants, use of carbapenem antibiotics, and age≥65 years were the risk factors for CRKP bloodstream infection in hospitalized patients within 1 month before infection (P＜0.05). The nomogram was verified, and the calibration curve fit well, H-L test χ2=7.630, P=0.366, and the AUC was 0.817 (95% CI: 0.739～0.895). Conclusions?Indwelling urinary catheter, indwelling central venous catheter, use of immunosuppressants, use of carbapenem antibiotics, and age≥65 years were the risk factors for CRKP bloodstream infection in hospitalized patients within 1 month before infection. The nomogram model constructed on this basis has a hign predictive value for CRKP bloodstream infection in hospitalized patients, and can provide reference for clinical medical staff to formulate individualized prevention and treatment strategiy. |