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| microRNA在HBV感染和致病中的作用研究进展 |
| Research progress on the role of microRNA in HBV infection and pathogenesis |
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| DOI：10.3969/j.issn.1007-8134.2022.05.016 |
| 中文关键词: 微小RNA 乙型肝炎病毒 相互作用 致病机制 |
| 英文关键词: miRNA HBV interaction pathogenesis |
| 基金项目:陆军军医大学士官学校面上项目（2022MS-01） |
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| 中文摘要: |
| [摘要]?微小RNA （microRNA, miRNA）在宿主-病毒相互作用中起关键调节作用，参与HBV感染、复制和HBV相关疾病的调节。细胞miRNA可以通过直接结合HBV转录物或通过靶向与HBV生命周期相关的细胞因子间接调节HBV转录和复制。反过来，HBV感染也可以影响宿主细胞内的miRNA水平。HBV和miRNA之间的相互作用在HBV复制和HBV相关疾病的发病机制中发挥重要作用。本文对miRNA与HBV的相互关系进行综述，为进一步探讨HBV感染致病的分子机制和开发新的抗HBV治疗策略提供参考。 |
| 英文摘要: |
| [Abstract] microRNAs (miRNAs) play a key regulatory role in host-virus interactions and participate in the regulation of HBV infection, replication, and HBV-related diseases. Cellular miRNA can regulate HBV transcription and replication either directly by binding HBV transcripts or indirectly by targeting molecular associated with the HBV life cycle. Conversely, HBV infection alters the species and abundance of cellular miRNA levels. The interaction between HBV and miRNA plays an important role in the replication and pathogenesis of HBV. In this review, the relationship between miRNA and HBV has been summarizreviewed for further understanding the molecular mechanisms of HBV infection and developing new antiviral treatment strategies. |
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