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| 慢性活动性EB病毒感染相关基因改变的研究进展 |
| Advances in genetic alterations associated with chronic active Epstein-Barr virus infection |
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| DOI：10.3969/j.issn.1007-8134.2023.03.016 |
| 中文关键词: EB病毒 慢性活动性EB病毒感染 致病机制 潜伏感染 裂解感染 |
| 英文关键词: Epstein-Barr virus CAEBV pathogenic mechanism latent infection lytic infection |
| 基金项目:“十三五”国家科技重大专项（2017ZX10204401） |
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| 中文摘要: |
| [摘要]? EB病毒（Epstein-Barr virus, EBV）属于疱疹病毒γ亚科，是导致传染性单核细胞增多症、慢性活动性EBV感染（chronic active Epstein-Barr virus infection, CAEBV）、多种淋巴细胞和上皮细胞相关恶性肿瘤的病原体。CAEBV属于EBV阳性T细胞或NK细胞增生性疾病，发病机制尚未明确，治疗方法有限，预后差。本文就CAEBV发病中相关基因改变的最新研究进展进行综述，为CAEBV的进一步研究和诊治提供依据。 |
| 英文摘要: |
| [Abstract] Epstein-Barr virus is the causal agent, a member of herpesvirus 4, which is associated with infectious mononucleosis, chronic active Epstein-Barr virus infection (CAEBV) and a range of malignancies from lymphocyte and epithelial cell. CAEBV belongs to EBV positive T cell or NK cell lymphoproliferative diseases. The pathogenesis of CAEBV remains unclear, the treatment options are limited with a poor prognosis. This article reviews the latest research progress of related gene changes in the pathogenesis of CAEBV, so as to provide a basis for further research on CAEBV diagnosis and therapy. |
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