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| 全血细胞计数来源的血液学免疫指标在预测肝硬化重症化中的作用 |
| Complete blood cell count-derived inflammatory markers for predicting progression from acute decompensation to acute-on-chronic liver failure in liver cirrhosis: current findings and future prospects |
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| DOI：10.3969/j.issn.1007-8134.2023.04.16 |
| 中文关键词: 肝硬化 急性失代偿 慢加急性肝衰竭 血液学免疫指标 全身性炎症 |
| 英文关键词: liver cirrhosis acute decompensation acute-on-chronic liver failure complete blood cell count-derived inflammatory markers systemic inflammation. |
| 基金项目:上海市自然科学基金项目（20ZR1456900） |
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| 中文摘要: |
| [摘要]?肝硬化（liver cirrhosis, LC）是一种常见的慢性肝病，易引发肝细胞癌和肝衰竭等严重并发症。急性失代偿（acute decompensation, AD）是LC严重损伤肝功能的表现，干预不及时可使LC进一步转化为慢加急性肝衰竭（acute-on-chronic liver failure, ACLF），增加致命风险。预防ACLF发生的关键是早期识别AD向ACLF转化，目前尚无预测评分系统可用于准确预测ACLF前期细菌感染。近期，有研究表明，全身性炎症是这一进程的主要机制之一，全血细胞计数来源的血液学免疫指标能反映全身炎症情况，可用于评价肝病进展。本文总结了这些指标在LC进展、尤其是AD向ACLF转化预测方面的最新研究，并对其未来在临床应用中的前景进行了探讨，希望能够早期识别细菌感染并预测从AD到ACLF的进展，提高LC患者的生存率。 |
| 英文摘要: |
| [Abstract] Liver cirrhosis (LC) is a common chronic liver disease that can lead to severe complications such as hepatocellular carcinoma and liver failure. Acute decompensation (AD) is a manifestation of severe liver function impairment in LC. Without timely intervention, LC can further progress to acute-on-chronic liver failure (ACLF), increasing the risk of fatality. The key to preventing the onset of ACLF is early recognition of the conversion from AD to ACLF. Currently, there is no predictive scoring system available to accurately predicting pre-ACLF infections. Recent studies indicates that systemic inflammation plays a significant role in this process. Hematological immune indicators derived from complete blood cell counts can reflect systemic inflammatory status and be used to evaluate the progression of liver disease. This article summarizes the latest research findings on these indicators in LC progression, especially in predicting the transformation from AD to ACLF, and discusses their potential in future clinical application. The aim is to detect infections early and predict the progression from AD to ACLF, thus improving survival rates of LC patients. |
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