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| 肾综合征出血热发病机制的研究进展 |
| Research progress on the pathogenesis of hemorrhagic fever with renal syndrome |
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| DOI：10.3969/j.issn.1007-8134.2020.03.001 |
| 中文关键词: 肾综合征出血热 汉坦病毒 汉滩病毒 发病机制 |
| 英文关键词: hemorrhagic fever with renal syndrome hantavirus hantaan virus pathogenesis |
| 基金项目:“十三五”国家科技重大专项（2017ZX10204401）；国家自然科学基金（81373118）；陕西省自然科学基金一般面上项目（2018JM7103） |
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| 中文摘要: |
| 肾综合征出血热（hemorrhagic fever with renal syndrome, HFRS）是由汉坦病毒感染引起的以发热、休克、出血和肾脏损害为主要特征的急性自然疫源性疾病。汉坦病毒主要感染人血管内皮细胞，引起小血管和毛细血管广泛损伤。血管通透性增加是HFRS临床表现的病理基础。国内外学者尽管在汉坦病毒致病机制方面开展了诸多研究，如病毒诱导的免疫病理反应、宿主遗传与细胞凋亡、血小板减少与功能障碍、血管内皮损伤等，但HFRS发病机制仍未完全阐明，也无特效治疗药物，深入探讨汉坦病毒致病的分子机制，寻找有效治疗药物仍是汉坦病毒/HFRS领域的研究热点。本文结合近年来国内外相关研究，阐述HFRS发病机制的研究进展。 |
| 英文摘要: |
| Hemorrhagic fever with renal syndrome (HFRS) is an acute natural epidemic disease characterized by fever, shock, hemorrhage and renal injury caused by hantavirus infection. Hantavirus mainly infects human vascular endothelial cells, and induces extensive damage to small blood vessels and capillaries. Increased vascular permeability is the pathological basis for clinical manifestations of HFRS. In recent years, although domestic and foreign scholars have carried out many studies on the pathogenesis of hantavirus, such as the immune pathological response induced by hantavirus, host genetics and apoptosis, thrombocytopenia and dysfunction and the vascular endothelial injury, the pathogenesis of HFRS has not been fully elucidated and there are no effective drugs yet. In-depth discussion of the molecular mechanism of HFRS pathogenesis and finding effective therapeutic drugs are still research hot-spots in the field of hantavirus/HFRS. This review elaborates the research progress on the pathogenesis of HFRS based on the domestic and foreign studies in recent years. |
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