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| 秦皇岛地区老年戊型肝炎流行病学及临床特征分析 |
| Epidemiology and clinical features of senile patients with hepatitis E in Qinhuangdao region |
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| DOI：10.3969/j.issn.1007-8134.2020.03.012 |
| 中文关键词: 戊型肝炎 老年 流行病学 临床特点 |
| 英文关键词: hepatitis E (HE) senile epidemiology clinical feature |
| 基金项目:河北省秦皇岛市科技研究与发展指导计划项目（201805A072） |
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| 中文摘要: |
| 目的 调查秦皇岛地区老年戊型肝炎（hepatitis E, HE）的流行病学和临床特点。方法 收集秦皇岛市第一医院诊治的老年HE患者（≥60岁）的临床资料，分析其流行病学和临床特点。结果 2015—2018年间来我院就诊的老年HE患者132例，其中男性102例，占73.27%。32例合并基础肝病，45例合并糖尿病、冠心病等其他慢性疾病。第4季度发病人数最多，占37.12%。与单纯老年HE患者比较，合并基础肝病的患者TBIL、ALT、AST水平显著增高，胆碱酯酶（cholinesterase, CHE）水平和PTA下降（P 均＜0.05）。与单纯老年HE患者比较，合并其他慢性疾病患者TBIL水平显著增高，PTA降低（P 均＜0.05）。单纯老年HE患者病死率为3.64%（2/55），合并基础肝病患者的病死率为21.88%（7/32），合并其他慢性疾病患者病死率为13.33%（6/45），3类患者病死率比较，差异有统计学意义（P ＜0.05）。结论 老年HE男性发病率显著高于女性，主要发生在第4季度，合并慢性疾病尤其基础肝病的老年患者病情较重，病死率较高。 |
| 英文摘要: |
| Objective To investigate the epidemiological and clinical features of senile patients with hepatitis E (HE) in Qinhuangdao. Methods Clinical data of senile patients (≥60 years old) with HE admitted to the First Hospital of Qinhuangdao were collected. Epidemiological characteristics and clinical profiles were analyzed. Results From 2015 to 2018, 132 senile patients with HE were treated in our hospital, and 102 (73.27%) of them were males. Thirty-two cases were complicated with underlying basic liver diseases, and 45 cases were complicated with other chronic diseases such as diabetes and coronary heart disease. The number of affected cases was dominant in the fourth quarter, accounting for 37.12%. Compared with senile patients with sporadic HE, those senile patients with liver diseases showed significantly higher TBIL, ALT, AST levels, lower cholinesterase (CHE) and PTA levels (P＜0.05). Compared with senile patients with sporadic HE, those senile patients with other chronic underlying diseases showed significantly a higher TBIL level, lower PTA level (P＜0.05). The case fatality rate of senile patients with sporadic HE was 3.64% (2/55), that of senile HE patients with liver diseases was 21.88% (7/32) and that of senile HE patients with other diseases was 13.33% (6/45), with statistically significant differences (P＜0.05). Conclusions The incidence of HE in male senile patients is significantly higher than that in female senile patients. HE in senile patients mainly occurrs in the fourth quarter. The medical condition of senile HE patients with chronic especially underlying liver diseases is relatively severe, with a high case fatality rate. |
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