Objective: To study the clinical characteristics, seasonal incidence, serum antibody and genotype of scrub typhus in Yunnan. Methods:In this study, 1033 scrub typhus patients reported online by Chinese Center for Disease Control and Prevention from January 2021 to December 2021 were selected as subjects to study the distribution characteristics of scrub typhus epidemiology, clinical symptoms, laboratory data, serological and genetic test results in Yunnan Province. Results: The prevalence of scrub typhus in Yunnan province was mostly male, aged between 41 and 60 years, mostly farmers, and the incidence was higher in autumn. The main clinical symptoms of the patients were fever, high fever (> 39℃), skin ulcers or eschar and chills. The main laboratory tests were eosinophils < 0.5*109/L, hemoglobin < 120g/L, C-reactive protein > 8mg/L and alanine aminotransferase > 50U/L. Serology was dominated by Kato and genotypes were dominated by groEL. Through phylogenetic tree analysis, GroEL genotypes of scrub typhus patients in Yunnan province were in the same branch as AH‐GD‐OT‐S6(GQ499933), UT332(EF551306), Kato(AY191586), Karp(M31887), and ZJ‐TT‐OT‐O21(GQ499953) strains reported clinically On.Conclusion:Special terrain to landscape in yunnan province, has become a popular one of the important areas of tsutsugamushi disease, with the continuous development of tourism industry, the province outside the genes group invasion has become one of the main reasons for diversification of the disease, suggest that clinical according to the flow characteristics of tsutsugamushi disease in yunnan province, early treatment of patients, improve the quality of life of people. |