| Objective Brucellosis is a persistent zoonosis in China, but there are few data in Beijing. This study aims to explore the clinical characteristics of brucellosis in children, so as to improve the treatment level of clinicians. Methods Clinical data of 40 cases of brucellosis patients admitted to the Department of Infection, Beijing You 'an Hospital, Capital Medical University from 2012 to 2022, including epidemiology, clinical features, laboratory examination and drug therapy, were selected and analyzed. Results Among the 40 patients, there were more females (22 cases, 55%) than males (18 cases, 45%). The minimum age was 5 months and the maximum age was 14 years. The median age was 4 years and 2 months. The main manifestations were fever (36 cases, 90%), hyperhidrosis (25 cases, 62.5%), leg pain (19 cases, 47.5%) and fatigue (18 cases, 45%). The white blood cell count of 32 cases (80%) was (4 ~ 10) ×109/L. Lymphocyte count increased in 36 cases (90%). The main organ injury was abnormal liver function. All cases were treated with at least 2 antimicrobials, including rifampicin, co-sulfamethoxazole, and doxycycline (for children ≥8 years old or older). In cases with complications, co-sulfamethoxazole or the third-generation cephalosporin were combined in basic treatment. Conclusion The symptoms of brucellosis in children are atypical, and the epidemiological history and fever are the main clues. However, with the development of tourism industry and aquaculture, the incidence of brucellosis in non-endemic areas has gradually increased. At the same time, the expression of children, especially infants, is unclear. For patients with complications, normal examination can not distinguish between growth pain and non-physiological pain, and it is easy to miss diagnosis and misdiagnosis, which adds great challenges to clinical work. |