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| 胸腔积液ESR、TGF-β1、IL-27对结核性胸膜炎预后的评估 |
| 胸腔积液ESR、TGF-β1、IL-27对结核性胸膜炎预后的评估 |
| 投稿时间：2023-11-10 修订日期：2024-04-29 |
| DOI： |
| 中文关键词: 胸腔积液 ESR TGF-β1 IL-27 结核性胸膜炎 预后 |
| 英文关键词: pleural effusion ESR TGF-β1 IL-27 Tuberculous pleurisy prognosis |
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| 中文摘要: |
| 【】目的:探讨分析胸腔积液ESR、TGF-β1、IL-27对结核性胸膜炎预后的评估价值。方法:选择2021年3月~2023年3月我院收治的184例结核性胸膜炎患者,根据患者治疗预后情况将患者分为预后良好组(n=146)、预后不良组(n=38)。收集并记录两组患者临床资料,并检测比较两组患者胸腔积液ESR、TGF-β1、IL-27水平,对可能影响患者临床预后的各因素进行单因素及多因素Logistic回归分析,采用ROC曲线分析患者胸腔积液ESR、TGF-β1、IL-27水平对不良预后预测价值。结果:两组临床资料比较,性别、糖尿病、高血压以及冠心病比较差异无统计学意义(P>0.05),而两组患者年龄、就诊时间、胸水细胞数、胸水蛋白总量比较差异具有统计学意义(P<0.05)。预后不良组患者胸腔积液ESR、TGF-β1、IL-27水平均显著高于预后良好组(P<0.05)。多因素Logistic回归分析结果显示,胸腔积液ESR、TGF-β1、IL-27以及胸水细胞数、胸水蛋白总量进入回归模型(P<0.05)。采用ROC曲线分析患者胸腔积液ESR、TGF-β1、IL-27水平对不良预后的预测价值,曲线下面积分别为0.787、0.852、0.892(P<0.05)。结论:结核性胸膜炎患者胸腔积液ESR、TGF-β1、IL-27可在一定程度上预测患者治疗预后,从而为患者病情评估以及治疗效果的评估提供一定的参考价值,值得临床进一步深入研究分析。 |
| 英文摘要: |
| Objective: To evaluate the prognostic value of pleural effusion ESR, TGF-β1 and IL-27 in tuberculous pleurisy. Methods: 184 patients with tuberculous pleurisy admitted to our hospital from March 2021 to March 2023 were selected and divided into good prognosis group (n=146) and poor prognosis group (n=38) according to the treatment and prognosis of the patients. Clinical data of the two groups of patients were collected and recorded, and the levels of ESR, TGF-β1 and IL-27 in pleural effusion of the two groups were measured and compared. Univariate and multivariate Logistic regression analysis was performed for various factors that may affect the clinical prognosis of the patients. ROC curve was used to analyze the predictive value of ESR, TGF-β1 and IL-27 in patients with pleural effusion. Results: There were no statistically significant differences in clinical data between the two groups in gender, diabetes, hypertension and coronary heart disease (P>0.05), but there were statistically significant differences in age, treatment time, number of pleural fluid cells and total pleural fluid protein between the two groups (P<0.05). The levels of ESR, TGF-β1 and IL-27 in pleural effusion in poor prognosis group were significantly higher than those in good prognosis group (P<0.05). Multivariate Logistic regression analysis showed that ESR, TGF-β1, IL-27, the number of pleural effusion cells and total pleural effusion protein entered the regression model (P<0.05). ROC curve was used to analyze the predictive value of ESR, TGF-β1 and IL-27 in patients with pleural effusion, and the areas under the curve were 0.787, 0.852 and 0.892, respectively (P<0.05). Conclusion: ESR, TGF-β1, and IL-27 in pleural effusion of patients with tuberculous pleurisy can predict the prognosis of patients to a certain extent, thus providing certain reference value for the evaluation of patients" condition and treatment effect, which is worthy of further clinical research and analysis. |
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