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| COVID-19合并肾功能损伤患者临床特征及影响因素分析 |
| Clinical characteristics and influencing factors of renal function impairment in COVID-19 patients |
| 投稿时间：2024-01-09 修订日期：2024-03-21 |
| DOI： |
| 中文关键词: COVID-19 肾功能异常 临床特征 影响因素 |
| 英文关键词: COVID-19 renal function impairment clinical characteristics influencing factor |
| 基金项目:新疆维吾尔自治区自然科学基金(2021D01A130) |
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| 中文摘要: |
| 目的 探讨新型冠状病毒感染（Corona Virus Disease 2019，COVID-19）合并肾功能损伤患者的临床特征及影响因素。方法 采用多中心回顾性临床研究，选取2020年7—9月和2022年10—12月收治于新疆医科大学第八附属医院及第四附属医院（新冠肺炎救治定点医院）住院的成人COVID-19患者。收集患者的一般及临床资料，并进行分析讨论。结果 498例确诊的COVID-19成人患者中，在住院期间出现肾功能损伤患者占比为23.29%（116/498），其中男性占比61.21%（71/116）。进展为急性肾损伤（Acute kidney injury,AKI）的患者占3.82%（19/498）。出现血肌酐升高的患者占5.42%（27/498），血尿素氮升高的患者占22.89%（114/498），出现蛋白尿阳性的患者占17.74%（82/498），尿潜血阳性的患者占21.17%（105/498）。COVID-19合并肾功能损伤可能不会延长患者的平均住院时间。男性、既往患有高血压、血小板计数<125.0×109/L、丙氨酸氨基转移酶>50.0U/L、D-二聚体>1.0μg/L、白介素-6>7.0pg/ml、血沉>20mm/h均是COVID-19成人患者发生肾功能损伤的独立危险因素。结论 COVID-19合并肾功能损害在临床需要引起关注，尽早识别危险人群，定期进行肾功能、肾脏超声和尿常规检查，是保护肾脏、延缓肾脏疾病进展的重要方式及手段。 |
| 英文摘要: |
| Objective To investigate the clinical features and influencing factors of patients with Corona Virus Disease 2019 (COVID-19) complicated with renal function injury.. Methods We did a multi-center retrospective clinical study was conducted to select adult patients with COVID-19 who were admitted to the Eighth and Fourth Affiliated Hospitals of Xinjiang Medical University (designated hospitals for the treatment of COVID-19) from July to September 2020 and October to December 2022. The general and clinical data of patients were collected and analyzed. Results In total, 498 hospitalized patients with COVID-19 were collected. During hospitalization, 23.29% of patients had renal impairment, and 61.21% were male. 3.82% of the patients progressed to AKI. 5.42% of patients had elevated Scr index and 22.89% of patients had elevated BUN index. Proteinuria was present in 17.74% of patients and hematuria was present in 21.17% of the patients. COVID-19 patients with renal function impairment does not prolong the overall hospital stay. Male, Preexisting hypertension, Platelet count <125.0×109/L, Alanine aminotransferase >50.0U/L, D-dimer >1.0μg/L, Interleukin-6 >7.0pg/ml, and ESR >20mm/h were all independent risk factors for renal function impairment in adult patients with COVID-19. Conclusion COVID-19 combined with renal function impairment is still relatively high in clinical practice, which needs much attention. The identification of dangerous population as soon as possible, regular kidney function, kidney ultrasound and routine urine examination are important ways to protect the COVID-19 patients. |
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