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| 四联抗结核致血小板减少脑出血死亡1例并文献复习 |
| A case of thrombocytopenia caused by tetrad antituberculosis died from cerebral hemorrhage and literature review |
| 投稿时间：2024-01-10 修订日期：2024-04-11 |
| DOI： |
| 中文关键词: 抗结核 血小板减少 紫癜 出血 |
| 英文关键词: Anti-tuberculosis thrombocytopenia Purpura hemorrhage |
| 基金项目:2019年四川省卫健委科研课题(普及应用项目)立项编号:19PJ113 |
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| 中文摘要: |
| 【】结核病治疗时间长,抗结核药物因联合用药、药物种类多样,服药周期长,在治疗过程中可能出现累及各个系统、不同程度、多种药物不良反应。其中血液系统异常较为常见,临床发现使用抗结核药物治疗后出现血小板减少者较多,可引起患者出血风险增大,严重时可出现重要脏器出血而危及生命。本文就1例使用四联抗结核治疗(利福平、吡嗪酰胺、乙胺丁醇、异烟肼)出现血小板重度减少,并发严重脑出血死亡的病例进行报道并结合文献复习,对该类病人的治疗进行探讨,以警示临床医师重视抗结核药物导致的血小板减少症,确保患者用药安全。 |
| 英文摘要: |
| 【 】 Tuberculosis treatment time is long, anti-tuberculosis drugs due to combination of drugs, drug types, long drug cycle, in the course of treatment may involve various systems, different degrees, multiple drug adverse reactions. Among them, abnormal blood system is more common, and clinical findings show that there are more thrombocytopenia after treatment with anti-tuberculosis drugs, which can lead to increased bleeding risk of patients, and serious bleeding of important organs can be life-threatening. In this paper, a case of severe thrombocytopenia complicated with severe cerebral hemorrhage after the use of quadruplex anti-tuberculosis therapy (rifampicin, pyrazinamide, ethambutol, isoniazid) was reported and the treatment of such patients was discussed in combination with literature review, so as to warn clinicians to pay attention to thrombocytopenia caused by anti-tuberculosis drugs and ensure the safety of drug use for patients. |
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