| Objective To evaluate the distribution characteristics of pathogens causing bloodstream infection in AIDS patients and the risk factors affecting the death of patients, so as to provide an effective foundation for improving the level of clinical diagnosis and treatment and reducing the mortality rate. Methods The clinical data of AIDS patients with BSI admitted to the emergency department of our hospital during 2022 were analyzed retrospectively, and the distribution of pathogenic bacteria was analyzed. According to the survival or death of patients during hospitalization, they were divided into survival group and death group. Logistic regression analysis was used to screen out independent risk factors affecting death. Results A total of 200 AIDS patients with BSI were admitted to the emergency department in 2022, and 232 strains of pathogenic bacteria were detected: 144 strains of fungi ( 62.07 % ), mainly Talaromyces marneffei ( 55.60 % ) ; there were 35 strains of Gram-negative bacteria ( 15.09 % ), mainly Salmonella enteritidis ( 3.88 % ) and Escherichia coli ( 3.88 % ). 16 strains of Mycobacterium ( 6.90 % ); there were 37 strains of Gram-positive bacteria ( 15.95 % ), Staphylococcus aureus (3.45%) and Staphylococcus epidermidis (3.45%). Among the 200 patients, 49 ( 24.5 % ) died and 151 ( 75.5 % ) survived. There was no difference in gender, age, white blood cell count, C-reactive protein , serum amyloid protein, hematocrit and CD4+T cells between the two groups.Univariate analysis showed that the platelet count, albumin, and endogenous creatinine clearance rate in the death group were lower than those in the survival group, while procalcitonin, multiple bacterial infections, septic shock, acute physiological and chronic health II scores, and sequential organ failure scores were higher than those in the survival group, which were risk factors for patient mortality, with statistically significant differences. Multivariate logistic regression analysis showed that a decrease in endogenous creatinine clearance rate (OR=1.035), septic shock (OR=10.443), and acute physiological and chronic health II score>25 (OR=7.708) were independent risk factors for patient mortality. Conclusion: The incidence of BSI in AIDS patients is high, and the pathogenic bacteria of bloodstream infections included in this study are mainly fungi, with a high mortality rate. Decreased Ccr, septic shock, and high APACHE II score are independent risk factors for mortality. |